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• W1993878868 abstract "Toxic effects of microcystin-LR were studied in hepatocytes isolated from fed and fasted juvenile goldfish Carassius auratus (30 g body weight). The hepatocytes were incubated with 10 μg MC-LR l−1 during 4 h. MC-LR induces no effect in terms of cell number and viability. The toxin accumulation pattern was different in fed and fasted treatments. MC-LR accumulated more rapidly in ‘fasted’ cells where the highest concentration was observed by 1 h of exposure. It was delayed to 4 h in the ‘fed’ cells. MC-LR accumulation induced a severe decrease in hepatic protein phosphatase activity in both treatments. It was almost totally inhibited in both treatments during the first hour of exposure. The glycogen content was significantly reduced after 2 h of exposure in the fasting treatments, but not in the feeding one." @default.
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• W1993878868 date "2004-12-01" @default.
• W1993878868 modified "2023-09-24" @default.
• W1993878868 title "Effect of microcystin-LR on protein phosphatase activity and glycogen content in isolated hepatocytes of fed and fasted juvenile goldfish Carassius auratus L." @default.
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• W1993878868 doi "https://doi.org/10.1016/j.toxicon.2004.09.003" @default.
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