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- W1993887172 startingPage "1178" @default.
- W1993887172 abstract "Cytochrome bd is a prokaryotic respiratory quinol:O2 oxidoreductase, phylogenetically unrelated to the extensively studied heme–copper oxidases (HCOs). The enzyme contributes to energy conservation by generating a proton motive force, though working with a lower energetic efficiency as compared to HCOs. Relevant to patho-physiology, members of the bd-family were shown to promote virulence in some pathogenic bacteria, which makes these enzymes of interest also as potential drug targets. Beyond its role in cell bioenergetics, cytochrome bd accomplishes several additional physiological functions, being apparently implicated in the response of the bacterial cell to a number of stress conditions. Compelling experimental evidence suggests that the enzyme enhances bacterial tolerance to oxidative and nitrosative stress conditions, owing to its unusually high nitric oxide (NO) dissociation rate and a notable catalase activity; the latter has been recently documented in one of the two bd-type oxidases of Escherichia coli. Current knowledge on cytochrome bd and its reactivity with O2, NO and H2O2 is summarized in this review in the light of the hypothesis that the preferential (over HCOs) expression of cytochrome bd in pathogenic bacteria may represent a strategy to evade the host immune attack based on production of NO and reactive oxygen species (ROS). This article is part of a Special Issue entitled: 18th European Bioenergetic Conference." @default.
- W1993887172 created "2016-06-24" @default.
- W1993887172 creator A5001298745 @default.
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- W1993887172 creator A5032073794 @default.
- W1993887172 creator A5035683021 @default.
- W1993887172 date "2014-07-01" @default.
- W1993887172 modified "2023-10-12" @default.
- W1993887172 title "Cytochrome bd oxidase and bacterial tolerance to oxidative and nitrosative stress" @default.
- W1993887172 cites W1484179725 @default.
- W1993887172 cites W1488793082 @default.
- W1993887172 cites W1529449066 @default.
- W1993887172 cites W1530145064 @default.
- W1993887172 cites W1560967394 @default.
- W1993887172 cites W158616869 @default.
- W1993887172 cites W1965295255 @default.
- W1993887172 cites W1965481505 @default.
- W1993887172 cites W1965552488 @default.
- W1993887172 cites W1967562126 @default.
- W1993887172 cites W1969930250 @default.
- W1993887172 cites W1970610666 @default.
- W1993887172 cites W1970727664 @default.
- W1993887172 cites W1971128407 @default.
- W1993887172 cites W1971692939 @default.
- W1993887172 cites W1973067213 @default.
- W1993887172 cites W1973255798 @default.
- W1993887172 cites W1973819022 @default.
- W1993887172 cites W1976362650 @default.
- W1993887172 cites W1979325055 @default.
- W1993887172 cites W1982715131 @default.
- W1993887172 cites W1983953766 @default.
- W1993887172 cites W1985293833 @default.
- W1993887172 cites W1986943833 @default.
- W1993887172 cites W1988857358 @default.
- W1993887172 cites W1994201422 @default.
- W1993887172 cites W1995466069 @default.
- W1993887172 cites W1998876687 @default.
- W1993887172 cites W1999878790 @default.
- W1993887172 cites W2003933756 @default.
- W1993887172 cites W200606638 @default.
- W1993887172 cites W2006418181 @default.
- W1993887172 cites W2009052965 @default.
- W1993887172 cites W2016214213 @default.
- W1993887172 cites W2017037692 @default.
- W1993887172 cites W2017329606 @default.
- W1993887172 cites W2017360675 @default.
- W1993887172 cites W2019640403 @default.
- W1993887172 cites W2022419949 @default.
- W1993887172 cites W2025116679 @default.
- W1993887172 cites W2025603698 @default.
- W1993887172 cites W2028734313 @default.
- W1993887172 cites W2030076441 @default.
- W1993887172 cites W2031571145 @default.
- W1993887172 cites W2034038257 @default.
- W1993887172 cites W2035671239 @default.
- W1993887172 cites W2039305495 @default.
- W1993887172 cites W2040763389 @default.
- W1993887172 cites W2041124801 @default.
- W1993887172 cites W2044621569 @default.
- W1993887172 cites W2047545717 @default.
- W1993887172 cites W2048281093 @default.
- W1993887172 cites W2048626265 @default.
- W1993887172 cites W2049322298 @default.
- W1993887172 cites W2055403585 @default.
- W1993887172 cites W2056468967 @default.
- W1993887172 cites W2059539744 @default.
- W1993887172 cites W2061557244 @default.
- W1993887172 cites W2061746072 @default.
- W1993887172 cites W2062054651 @default.
- W1993887172 cites W2062930912 @default.
- W1993887172 cites W2064423062 @default.
- W1993887172 cites W2067086084 @default.
- W1993887172 cites W2067879558 @default.
- W1993887172 cites W2068537834 @default.
- W1993887172 cites W2069648641 @default.
- W1993887172 cites W2069842714 @default.
- W1993887172 cites W2070260833 @default.
- W1993887172 cites W2071103471 @default.
- W1993887172 cites W2073050582 @default.
- W1993887172 cites W2073210360 @default.
- W1993887172 cites W2074335496 @default.
- W1993887172 cites W2074507716 @default.
- W1993887172 cites W2077215077 @default.
- W1993887172 cites W2080967955 @default.
- W1993887172 cites W2089457445 @default.
- W1993887172 cites W2092045222 @default.
- W1993887172 cites W2096901494 @default.
- W1993887172 cites W2098164667 @default.
- W1993887172 cites W2100064409 @default.
- W1993887172 cites W2103046890 @default.
- W1993887172 cites W2104106601 @default.
- W1993887172 cites W2105840458 @default.
- W1993887172 cites W2107272825 @default.
- W1993887172 cites W2119423322 @default.
- W1993887172 cites W2120439433 @default.
- W1993887172 cites W2121017928 @default.
- W1993887172 cites W2123800743 @default.