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- W1993887462 abstract "An indole alkaloid, teleocidin, induced phenotypic differentiation in the thymic ALL cell line HPB-ALL. Within 30 min of seeding in the presence of teleocidin, the cells formed a smooth round shape. Upon 5-day exposure to teleocidin, most of the cells became smaller and reminiscent of large or atypical lymphocytes. A thymic antigen stained with monoclonal antibody OKT6 was remarkably reduced while Leu2a-positive cells were increased in the treated cells. Upon teleocidin-induced phenotypic differentiation, the growth rate of cells was inhibited, their ability to incorporate DNA via [3H]-labelled precursors was reduced, their ability to bind sRBC rosettes was increased. These changes were paralleled to that induced by 12-o-tetradecanoyl-phorbol-13-acetate." @default.
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- W1993887462 date "1983-01-01" @default.
- W1993887462 modified "2023-10-17" @default.
- W1993887462 title "Teleocidin-Induced Phenotypic Changes in Thymic ALL Cell Line, HPB-ALL" @default.
- W1993887462 doi "https://doi.org/10.1159/000225742" @default.
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