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- W1993889126 abstract "Research has consistently shown that individuals with type 2 diabetes have lower aerobic capacities and less improvement with training compared to healthy counterparts, for reasons that are yet unknown. The purpose of this study was to examine the influence of glycosylated hemoglobin (HbA1c) on maximal oxygen consumption (VO2max), and to explore the role of 2,3 BPG in this relationship. Subjects were 26 middle-age (48.8 ± 5.5 yrs) women, 19 [10 normoglycemic (N) and 9 hyperglycemic (H)] of whom exercised with personal trainers for 15 wks (3 x/wk, 30–45 min, 50–85% VO2max) and 7 who served as controls (C). HbA1c, 2,3 BPG and VO2max were measured at baseline (T1) and posttest (T2). ANCOVA/ANOVA found significant (p < .05) differences at T1 and T2 between groups in HbA1c (T1:C =5.6%, N = 5.0%, H = 7.0% and T2:C = 5.7%, N = 4.8%, H = 6.8%) and VO2max (T1:C = 19.8, N = 22.8, H = 19.3 and T2:C = 19.8, N = 24.6, H = 21.0 ml/kg/min). Exercise groups improved from T1 to T2 in HbA1c (N = 4%, H = 3%, NS) and VO2max (N = 8%, H = 9%, p = .04). HbA1c and VO2max were correlated (p < .05) at T1 (r = −.55) and T2, (r = −.38). 2,3 BPG was not related to HbA1c or VO2max T1 or T2, nor did it differ among the groups. However, subjects with HbA1c ≥ 8% had lower 2,3 BPG levels than subjects with HbA1c ≤ 7.9% (9.6 vs. 14.1 μmol/g, p = .02). This study showed that glycemic control and aerobic capacity can improve as much in hyperglycemic as normoglycemic women following moderate intensity, closely supervised exercise training, despite initial differences in HbA1c and VO2max. Supported by a grant from the Purdue Research Foundation" @default.
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- W1993889126 date "2001-05-01" @default.
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- W1993889126 title "THE INFLUENCE OF GLYCOSYLATED HEMOGLOBIN ON OXYGEN CONSUMPTION IN WOMEN" @default.
- W1993889126 doi "https://doi.org/10.1097/00005768-200105001-01786" @default.
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