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• W1993889400 abstract "Analysis of total and individual fecal neutral steroids in different groups of intestinal pathology from 105 patients was performed to investigate a relationship between neutral steroid concentration and malignant potentiality of colon cells. The fecal concentration of total neutral steroids was significantly higher in patients with colon cancer (57.3 ± 2.4 mmol/kg of wet feces) and patients with malignant degenerative polyps at Stage I or II (49.5 ± 2.9) compared with controls (36.9 ± 3.5) as well as patients with adenomatous polyps (22.4 ± 2.0). Moreover, a significant correlation was found between total neutral steroid concentrations and coprostanol concentrations in patients with colon cancer (r = 0.928) and in patients with malignant polyps (r = 0.915). Coprostanol results only from the biohydrogenation of Δ 5-3β-OH steroids by anerobic bacteria because the analysis of a malignant colon tumor in comparison with a healthy colon wall showed that cholesterol is the only steroid included in membrane cells, and that the incubation of Clostridium or Bacteroides with Δ5-3β-OH steroids, such as cholesterol (steroid of animal origin) or β-sitosterol (steroid of plant origin) converts these steroids into coprostanol at a level of efficiency greater than 45%. The findings suggest that high levels of coprostanol reflecting a high growth of anerobic bacteria through the gut are related to the malignant potentiality of colon cells. The screening of neutral fecal steroids should provide a valuable parameter for predicting the malignancy of colon cells." @default.
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• W1993889400 date "1987-09-01" @default.
• W1993889400 modified "2023-09-26" @default.
• W1993889400 title "Relationship between fecal neutral steroid concentrations and malignancy in colon cells" @default.
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• W1993889400 doi "https://doi.org/10.1002/1097-0142(19870901)60:5<994::aid-cncr2820600513>3.0.co;2-r" @default.
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