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• W1993889788 endingPage "R1134" @default.
• W1993889788 startingPage "R1127" @default.
• W1993889788 abstract "Eryptosis, a suicidal death of mature erythrocytes, is characterized by decrease of cell volume, cell membrane blebbing, and breakdown of cell membrane asymmetry with phosphatidylserine exposure at the cell surface. Triggers of eryptosis include increased cytosolic Ca 2+ activity, which could result from activation of Ca 2+ -permeable cation channels. Ca 2+ triggers phosphatidylserine exposure and activates Ca 2+ -sensitive K + channels, leading to cellular K + loss and cell shrinkage. The cation channels and thus eryptosis are stimulated by Cl − removal and inhibited by erythropoietin. The present experiments explored eryptosis in transgenic mice overexpressing erythropoietin (tg6). Erythrocytes were drawn from tg6 mice and their wild-type littermates (WT). Phosphatidylserine exposure was estimated from annexin binding and cell volume from forward scatter in fluorescence-activated cell sorting (FACS) analysis. The percentage of annexin binding was significantly larger and forward scatter significantly smaller in tg6 than in WT erythrocytes. Transgenic erythrocytes were significantly more resistant to osmotic lysis than WT erythrocytes. Cl − removal and exposure to the Ca 2+ ionophore ionomycin (1 μM) increased annexin binding and decreased forward scatter, effects larger in tg6 than in WT erythrocytes. The K + ionophore valinomycin (10 nM) triggered eryptosis in both tg6 and WT erythrocytes and abrogated differences between genotypes. An increase of extracellular K + concentration to 125 mM blunted the difference between tg6 and WT erythrocytes. Fluo-3 fluorescence reflecting cytosolic Ca 2+ activity was larger in tg6 than in WT erythrocytes. In conclusion, circulating erythrocytes from tg6 mice are sensitized to triggers of eryptosis but more resistant to osmotic lysis, properties at least partially due to enhanced Ca 2+ entry and increased K + channel activity." @default.
• W1993889788 created "2016-06-24" @default.
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• W1993889788 date "2007-09-01" @default.
• W1993889788 modified "2023-10-04" @default.
• W1993889788 title "Enhanced susceptibility to suicidal death of erythrocytes from transgenic mice overexpressing erythropoietin" @default.
• W1993889788 cites W1504741434 @default.
• W1993889788 cites W155057202 @default.
• W1993889788 cites W1968426875 @default.
• W1993889788 cites W1969120266 @default.
• W1993889788 cites W1969886439 @default.
• W1993889788 cites W1970395279 @default.
• W1993889788 cites W1972130056 @default.
• W1993889788 cites W1972748726 @default.
• W1993889788 cites W1975003156 @default.
• W1993889788 cites W1975280842 @default.
• W1993889788 cites W1976466808 @default.
• W1993889788 cites W1979572339 @default.
• W1993889788 cites W1983418648 @default.
• W1993889788 cites W1991870376 @default.
• W1993889788 cites W1996179257 @default.
• W1993889788 cites W2003505368 @default.
• W1993889788 cites W2007310802 @default.
• W1993889788 cites W2015717266 @default.
• W1993889788 cites W2016415763 @default.
• W1993889788 cites W2025722101 @default.
• W1993889788 cites W2026924145 @default.
• W1993889788 cites W2027851046 @default.
• W1993889788 cites W2028628328 @default.
• W1993889788 cites W2030570585 @default.
• W1993889788 cites W2031230249 @default.
• W1993889788 cites W2033035828 @default.
• W1993889788 cites W2037885157 @default.
• W1993889788 cites W2038819783 @default.
• W1993889788 cites W2039659095 @default.
• W1993889788 cites W2042948104 @default.
• W1993889788 cites W2043994824 @default.
• W1993889788 cites W2045711003 @default.
• W1993889788 cites W2048692719 @default.
• W1993889788 cites W2050571341 @default.
• W1993889788 cites W2052492629 @default.
• W1993889788 cites W2052726190 @default.
• W1993889788 cites W2054696431 @default.
• W1993889788 cites W2057203237 @default.
• W1993889788 cites W2058108841 @default.
• W1993889788 cites W2061626577 @default.
• W1993889788 cites W2062984099 @default.
• W1993889788 cites W2064821447 @default.
• W1993889788 cites W2065641335 @default.
• W1993889788 cites W2066580845 @default.
• W1993889788 cites W2074702983 @default.
• W1993889788 cites W2075822475 @default.
• W1993889788 cites W2076273704 @default.
• W1993889788 cites W2080934825 @default.
• W1993889788 cites W2082490296 @default.
• W1993889788 cites W2088533769 @default.
• W1993889788 cites W2088972036 @default.
• W1993889788 cites W2090949880 @default.
• W1993889788 cites W2095372525 @default.
• W1993889788 cites W2095784946 @default.
• W1993889788 cites W2096188040 @default.
• W1993889788 cites W2097681180 @default.
• W1993889788 cites W2098000156 @default.
• W1993889788 cites W2101632221 @default.
• W1993889788 cites W2102807564 @default.
• W1993889788 cites W2105619315 @default.
• W1993889788 cites W2111015204 @default.
• W1993889788 cites W2111937773 @default.
• W1993889788 cites W2113053099 @default.
• W1993889788 cites W2116041955 @default.
• W1993889788 cites W2127353140 @default.
• W1993889788 cites W2131523916 @default.
• W1993889788 cites W2132153731 @default.
• W1993889788 cites W2139953109 @default.
• W1993889788 cites W2143999949 @default.
• W1993889788 cites W2148045277 @default.
• W1993889788 cites W2148394321 @default.
• W1993889788 cites W2153422264 @default.
• W1993889788 cites W2155261780 @default.
• W1993889788 cites W2155670471 @default.
• W1993889788 cites W2162988042 @default.
• W1993889788 cites W2169230321 @default.
• W1993889788 cites W2170961323 @default.
• W1993889788 cites W2172224722 @default.
• W1993889788 cites W2270697961 @default.
• W1993889788 cites W2335402586 @default.
• W1993889788 cites W4248717353 @default.
• W1993889788 doi "https://doi.org/10.1152/ajpregu.00110.2007" @default.
• W1993889788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17567717" @default.
• W1993889788 hasPublicationYear "2007" @default.
• W1993889788 type Work @default.

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