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- W1993901069 abstract "To improve our understanding of the cutaneous vitamin D system, we studied vitamin D receptor (VDR) gene regulation in cultured human keratinocytes. Because VDR and its ligand 1α,25-dihydroxyvitamin D3 have been implicated in epidermal growth control, we investigated VDR expression as related to cellular proliferation by using different cell cycle synchronization protocols. Keratinocytes, deprived of growth factors, were forced into quiescence and a concomitant loss of VDR expression was observed. Mitogenic stimulation of these G0 cells however quickly upregulated VDR levels several hours ahead the G1-S transition point. Growth arrest at the G1-S border by mimosine treatment or at the metaphase by nocodazole also downregulated VDR levels but a restoration of VDR expression was again quickly achieved after reentering the cell cycle. These findings indicate that VDR expression in keratinocytes is restricted to actively cycling cells, but not limited to one particular phase of the cell cycle." @default.
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- W1993901069 date "2000-12-01" @default.
- W1993901069 modified "2023-10-03" @default.
- W1993901069 title "Vitamin D Receptor Expression Is Linked to Cell Cycle Control in Normal Human Keratinocytes" @default.
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- W1993901069 doi "https://doi.org/10.1006/bbrc.2000.3892" @default.
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