Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993911704> ?p ?o ?g. }
- W1993911704 endingPage "322" @default.
- W1993911704 startingPage "305" @default.
- W1993911704 abstract "Membrane grafting of methoxypoly(ethylene glycol) [mPEG] to allogeneic leukocytes attenuates allorecognition and significantly reduces the risk of graft-versus-host disease in mice. To optimize the immunological efficacy of polymer grafting, murine splenocytes were modified using three differing linker chemistries: CmPEG (5 kDa), BTCmPEG (5 and 20 kDa) and TmPEG (5 kDa). In vitro immunocamouflage efficacy was examined by flow cytometic analysis of leukocyte markers and mixed lymphocyte reactions (MLR). In contrast to CmPEG and BTCmPEG, TmPEG exerted significant cellular toxicity. Flow cytometric analysis demonstrated that both CmPEG and BTCmPEG were highly effective at camouflaging cell surface markers while TmPEG was ineffective. Furthermore, CmPEG and BTCmPEG dramatically blocked MLR allorecognition and cellular proliferation. Polymer length was the most critical factor in the immunocamouflage of cells with the BTCmPEG 20 kDa being the most effective. In contrast to other immunomodulatory approaches, immunocamouflage of leukocytes yields a multivalent effect globally interfering with attachment, allorecognition, presentation and costimulation pathways." @default.
- W1993911704 created "2016-06-24" @default.
- W1993911704 creator A5006269410 @default.
- W1993911704 creator A5029499951 @default.
- W1993911704 date "2006-01-01" @default.
- W1993911704 modified "2023-09-27" @default.
- W1993911704 title "Comparative Analysis of Polymer and Linker Chemistries on the Efficacy of Immunocamouflage of Murine Leukocytes" @default.
- W1993911704 cites W1490299254 @default.
- W1993911704 cites W1555210583 @default.
- W1993911704 cites W1561844029 @default.
- W1993911704 cites W1564872934 @default.
- W1993911704 cites W1965918908 @default.
- W1993911704 cites W1971205391 @default.
- W1993911704 cites W1974454529 @default.
- W1993911704 cites W1988428180 @default.
- W1993911704 cites W1996299884 @default.
- W1993911704 cites W2000333405 @default.
- W1993911704 cites W2011370547 @default.
- W1993911704 cites W2011525185 @default.
- W1993911704 cites W2013733201 @default.
- W1993911704 cites W2017471025 @default.
- W1993911704 cites W2021203988 @default.
- W1993911704 cites W2027696154 @default.
- W1993911704 cites W2032242870 @default.
- W1993911704 cites W2042542087 @default.
- W1993911704 cites W2043817081 @default.
- W1993911704 cites W2049079105 @default.
- W1993911704 cites W2050348119 @default.
- W1993911704 cites W2050735645 @default.
- W1993911704 cites W2052842550 @default.
- W1993911704 cites W2055223867 @default.
- W1993911704 cites W2056445131 @default.
- W1993911704 cites W2067353129 @default.
- W1993911704 cites W207352142 @default.
- W1993911704 cites W2075535031 @default.
- W1993911704 cites W2085412899 @default.
- W1993911704 cites W2087061270 @default.
- W1993911704 cites W2112074257 @default.
- W1993911704 cites W2114799675 @default.
- W1993911704 cites W2122409167 @default.
- W1993911704 cites W2124952812 @default.
- W1993911704 cites W2156945455 @default.
- W1993911704 cites W2162505722 @default.
- W1993911704 cites W2172383460 @default.
- W1993911704 cites W2254140844 @default.
- W1993911704 cites W40471780 @default.
- W1993911704 doi "https://doi.org/10.1080/10731190600683845" @default.
- W1993911704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16809132" @default.
- W1993911704 hasPublicationYear "2006" @default.
- W1993911704 type Work @default.
- W1993911704 sameAs 1993911704 @default.
- W1993911704 citedByCount "26" @default.
- W1993911704 countsByYear W19939117042012 @default.
- W1993911704 countsByYear W19939117042014 @default.
- W1993911704 countsByYear W19939117042015 @default.
- W1993911704 countsByYear W19939117042016 @default.
- W1993911704 countsByYear W19939117042017 @default.
- W1993911704 countsByYear W19939117042018 @default.
- W1993911704 countsByYear W19939117042019 @default.
- W1993911704 countsByYear W19939117042020 @default.
- W1993911704 crossrefType "journal-article" @default.
- W1993911704 hasAuthorship W1993911704A5006269410 @default.
- W1993911704 hasAuthorship W1993911704A5029499951 @default.
- W1993911704 hasConcept C111919701 @default.
- W1993911704 hasConcept C1491633281 @default.
- W1993911704 hasConcept C178790620 @default.
- W1993911704 hasConcept C185592680 @default.
- W1993911704 hasConcept C200315206 @default.
- W1993911704 hasConcept C202751555 @default.
- W1993911704 hasConcept C203014093 @default.
- W1993911704 hasConcept C2775937945 @default.
- W1993911704 hasConcept C2776090121 @default.
- W1993911704 hasConcept C2778740727 @default.
- W1993911704 hasConcept C2780557392 @default.
- W1993911704 hasConcept C41008148 @default.
- W1993911704 hasConcept C521977710 @default.
- W1993911704 hasConcept C55493867 @default.
- W1993911704 hasConcept C86803240 @default.
- W1993911704 hasConcept C8891405 @default.
- W1993911704 hasConcept C95444343 @default.
- W1993911704 hasConceptScore W1993911704C111919701 @default.
- W1993911704 hasConceptScore W1993911704C1491633281 @default.
- W1993911704 hasConceptScore W1993911704C178790620 @default.
- W1993911704 hasConceptScore W1993911704C185592680 @default.
- W1993911704 hasConceptScore W1993911704C200315206 @default.
- W1993911704 hasConceptScore W1993911704C202751555 @default.
- W1993911704 hasConceptScore W1993911704C203014093 @default.
- W1993911704 hasConceptScore W1993911704C2775937945 @default.
- W1993911704 hasConceptScore W1993911704C2776090121 @default.
- W1993911704 hasConceptScore W1993911704C2778740727 @default.
- W1993911704 hasConceptScore W1993911704C2780557392 @default.
- W1993911704 hasConceptScore W1993911704C41008148 @default.
- W1993911704 hasConceptScore W1993911704C521977710 @default.
- W1993911704 hasConceptScore W1993911704C55493867 @default.
- W1993911704 hasConceptScore W1993911704C86803240 @default.
- W1993911704 hasConceptScore W1993911704C8891405 @default.
- W1993911704 hasConceptScore W1993911704C95444343 @default.
- W1993911704 hasIssue "3" @default.