FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993916998> ?p ?o ?g. }

• W1993916998 endingPage "2333" @default.
• W1993916998 startingPage "2328" @default.
• W1993916998 abstract "The C-terminal domain (CTD) of the largest subunit of RNA polymerase II (RNAPII) is heavily phosphorylated during the transition from transcription initiation to the establishment of an elongation-competent transcription complex. FCP1 is the only phosphatase known to be specific for the CTD of the largest subunit of RNAPII, and its activity is believed to be required to reactivate RNAPII, so that RNAPII can enter another round of transcription. We demonstrate that FCP1 is a phosphoprotein, and that phosphorylation regulates FCP1 activities. FCP1 is phosphorylated at multiple sites in vivo. The CTD phosphatase activity of phosphorylated FCP1 is stimulated by TFIIF, whereas dephosphorylated FCP1 is not. In addition to its role in the recycling of RNAPII, FCP1 also affects transcription elongation. Phosphorylated FCP1 is more active in stimulating transcription elongation than the dephosphorylated form of FCP1. We found that only phosphorylated FCP1 can physically interact with TFIIF. We set out to purify an FCP1 kinase from HeLa cells and identified casein kinase 2, which, surprisingly, displayed a negative effect on FCP1-associated activities." @default.
• W1993916998 created "2016-06-24" @default.
• W1993916998 creator A5009347072 @default.
• W1993916998 creator A5016384926 @default.
• W1993916998 creator A5055736230 @default.
• W1993916998 creator A5081220700 @default.
• W1993916998 creator A5082796663 @default.
• W1993916998 date "2003-02-18" @default.
• W1993916998 modified "2023-09-27" @default.
• W1993916998 title "The C-terminal domain phosphatase and transcription elongation activities of FCP1 are regulated by phosphorylation" @default.
• W1993916998 cites W1491081689 @default.
• W1993916998 cites W1497913243 @default.
• W1993916998 cites W1577470317 @default.
• W1993916998 cites W1578647589 @default.
• W1993916998 cites W1606267994 @default.
• W1993916998 cites W1656358829 @default.
• W1993916998 cites W1965591721 @default.
• W1993916998 cites W1973000551 @default.
• W1993916998 cites W1976425824 @default.
• W1993916998 cites W1996658265 @default.
• W1993916998 cites W1998812756 @default.
• W1993916998 cites W2004926093 @default.
• W1993916998 cites W2006028144 @default.
• W1993916998 cites W2019429295 @default.
• W1993916998 cites W2019583554 @default.
• W1993916998 cites W2030180039 @default.
• W1993916998 cites W2030401341 @default.
• W1993916998 cites W2044528352 @default.
• W1993916998 cites W2045766250 @default.
• W1993916998 cites W2064050024 @default.
• W1993916998 cites W2072836045 @default.
• W1993916998 cites W2076100163 @default.
• W1993916998 cites W2078023221 @default.
• W1993916998 cites W2078036317 @default.
• W1993916998 cites W2084374334 @default.
• W1993916998 cites W2085515309 @default.
• W1993916998 cites W2094184203 @default.
• W1993916998 cites W2094940061 @default.
• W1993916998 cites W2100649212 @default.
• W1993916998 cites W2103010558 @default.
• W1993916998 cites W2104531065 @default.
• W1993916998 cites W2111417873 @default.
• W1993916998 cites W2129709083 @default.
• W1993916998 cites W2141373343 @default.
• W1993916998 cites W2146366033 @default.
• W1993916998 cites W2151310103 @default.
• W1993916998 cites W2151788241 @default.
• W1993916998 cites W2155383176 @default.
• W1993916998 cites W2164154631 @default.
• W1993916998 doi "https://doi.org/10.1073/pnas.2628049100" @default.
• W1993916998 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/151340" @default.
• W1993916998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12591939" @default.
• W1993916998 hasPublicationYear "2003" @default.
• W1993916998 type Work @default.
• W1993916998 sameAs 1993916998 @default.
• W1993916998 citedByCount "30" @default.
• W1993916998 countsByYear W19939169982012 @default.
• W1993916998 countsByYear W19939169982013 @default.
• W1993916998 countsByYear W19939169982016 @default.
• W1993916998 countsByYear W19939169982017 @default.
• W1993916998 countsByYear W19939169982020 @default.
• W1993916998 countsByYear W19939169982021 @default.
• W1993916998 countsByYear W19939169982022 @default.
• W1993916998 countsByYear W19939169982023 @default.
• W1993916998 crossrefType "journal-article" @default.
• W1993916998 hasAuthorship W1993916998A5009347072 @default.
• W1993916998 hasAuthorship W1993916998A5016384926 @default.
• W1993916998 hasAuthorship W1993916998A5055736230 @default.
• W1993916998 hasAuthorship W1993916998A5081220700 @default.
• W1993916998 hasAuthorship W1993916998A5082796663 @default.
• W1993916998 hasBestOaLocation W19939169982 @default.
• W1993916998 hasConcept C101762097 @default.
• W1993916998 hasConcept C104317684 @default.
• W1993916998 hasConcept C11960822 @default.
• W1993916998 hasConcept C138885662 @default.
• W1993916998 hasConcept C150194340 @default.
• W1993916998 hasConcept C154816499 @default.
• W1993916998 hasConcept C156951783 @default.
• W1993916998 hasConcept C179926584 @default.
• W1993916998 hasConcept C184235292 @default.
• W1993916998 hasConcept C196117886 @default.
• W1993916998 hasConcept C2776449523 @default.
• W1993916998 hasConcept C41895202 @default.
• W1993916998 hasConcept C55493867 @default.
• W1993916998 hasConcept C64350747 @default.
• W1993916998 hasConcept C67705224 @default.
• W1993916998 hasConcept C86803240 @default.
• W1993916998 hasConcept C95444343 @default.
• W1993916998 hasConceptScore W1993916998C101762097 @default.
• W1993916998 hasConceptScore W1993916998C104317684 @default.
• W1993916998 hasConceptScore W1993916998C11960822 @default.
• W1993916998 hasConceptScore W1993916998C138885662 @default.
• W1993916998 hasConceptScore W1993916998C150194340 @default.
• W1993916998 hasConceptScore W1993916998C154816499 @default.
• W1993916998 hasConceptScore W1993916998C156951783 @default.
• W1993916998 hasConceptScore W1993916998C179926584 @default.
• W1993916998 hasConceptScore W1993916998C184235292 @default.
• W1993916998 hasConceptScore W1993916998C196117886 @default.

• next