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• W1993920694 abstract "Abstract Two monoamide derivatives of 1,4,7‐triazacyclononane‐1,4,7‐triacetic acid (NOTA) conjugated with methylamine ( 4 ) or benzylamine ( 5 ) were synthesized by treating di‐ tert ‐butyl 1,4,7‐triazacyclononane‐1,4‐diacetate ( 1 ) with 2‐chloro‐ N ‐benzyl‐ or ‐ N ‐methylacetamide, followed by an acid cleavage reaction. Complexes of 4 and 5 chelated to Ga 3+ to give Ga‐ 4 and Ga‐ 5 , respectively, in reaction solutions at different pH values (3 and 5). Complexes Ga‐ 4 and Ga‐ 5 were characterized by single‐crystal X‐ray diffraction and multinuclear NMR spectroscopy. In the solid state, these complexes were isostructural, and the coordination spheres of the metal ions exhibited distorted octahedral geometries. In the case of the Ga‐ 4 complex, which was formed at both pH values, the metal ion is coordinated to the amide nitrogen atom of the modified pendent arm of 4 . However, in the case of Ga‐ 5 , the metal ion is coordinated to a nitrogen or an oxygen atom of the amide linkage when the pH of the reaction soultion was 5 or 3, respectively. No significant difference was found between the 1 H NMR spectra of the complexes formed at pH = 3 and 5. However, 71 Ga NMR spectra showed a broad resonance signal and a narrow singlet for the complex synthesized at the lower pH, but only a single narrow singlet for the complex prepared at neutral pH. Variable‐temperature 1 H NMR spectra showed that complexes Ga‐ 4 and Ga‐ 5 are rigid in solution. The stability of these complexes in the physiological pH range and at high temperature suggests that NOTA can be used as a bifunctional chelating agent to label biomolecules with radioactive gallium by direct conjugation of the complex to target molecules. This finding could open up a wide range of applications for NOTA‐type bifunctional chelating agents by eliminating the multi‐step synthesis routes required to introduce extra linker groups to the labelling agent." @default.
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• W1993920694 date "2010-10-27" @default.
• W1993920694 modified "2023-09-26" @default.
• W1993920694 title "Formation and Characterization of Gallium(III) Complexes with Monoamide Derivatives of 1,4,7‐Triazacyclononane‐1,4,7‐triacetic Acid: A Study of the Dependency of Structure on Reaction pH" @default.
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• W1993920694 doi "https://doi.org/10.1002/ejic.201000748" @default.
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