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- W1993921301 abstract "Leprosy is an old, still dreaded infectious disease caused by the obligate intracellular bacterium Mycobacterium leprae . During the infectious process, M. leprae is faced with the host macrophagic environment, where the oxidative stress and NO release, combined with low pH, low pO 2, and high pCO 2, contribute to limit the growth of the bacilli. Comparative genomics has unraveled massive gene decay in M. leprae, linking the strictly parasitic lifestyle with the reductive genome evolution. Compared with Mycobacterium tuberculosis and Mycobacterium bovis, the leprosy bacillus has lost most of the genes involved in the detoxification of reactive oxygen and nitrogen species. The very low reactivity of the unique truncated hemoglobin retained by M. leprae could account for the susceptibility of this exceptionally slow-growing microbe to NO." @default.
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- W1993921301 date "2002-09-01" @default.
- W1993921301 modified "2023-10-11" @default.
- W1993921301 title "Nitric Oxide and Mycobacterium leprae Pathogenicity" @default.
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- W1993921301 doi "https://doi.org/10.1080/15216540214542" @default.
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