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• W1993925554 abstract "Objective We have previously demonstrated that leukocyte delivery to remote sites is decreased in sepsis and that increased concentrations of soluble L-selectin are, in part, responsible for this finding. Given that leukocytes have been implicated in the pathogenesis of vascular leakage, we hypothesized that the elevated soluble L-selectin concentrations in sepsis may translate into decreased inflammation-mediated leukocyte-endothelial cell interactions and vascular leakage at these sites. Design Prospective, controlled animal study. Setting Surgical research laboratory in a university hospital. Subjects Swiss white male mice weighing 25–35 g. Interventions Mice were randomized to one of three study groups: intracremaster tumor necrosis factor-α with subsequent intravenous bicarbonate buffered solution; intracremaster tumor necrosis factor-α with intravenous soluble L-selectin (10 μg/mL); and intracremaster bicarbonate buffered solution with intravenous bicarbonate buffered solution. The cremaster muscle was prepared for both light and fluorescence intravital microscopy 2 hrs after intracremaster injection, and fluorescein isothiocyanate-labeled albumin was injected intravenously. Leukocyte-endothelial interactions (rolling flux, rolling velocity, and adherence) were counted off-line. Postcapillary venule leakage was determined by the permeability index (perivenular/intravenular fluorescence) after intravenous injection of fluorescent albumin. Measurements and Main Results Soluble L-selectin significantly attenuated tumor necrosis factor-α-mediated increases in leukocyte adherence and vascular leakage. Leukocyte rolling velocity was restored to baseline with soluble L-selectin; however, rolling flux was not altered. Blood pressure, shear rate, and leukocyte counts did not differ between groups. Conclusions Soluble L-selectin decreases local inflammation-mediated leukocyte adherence and vascular leakage in vivo. The increased concentrations of soluble L-selectin in sepsis may represent a protective mechanism by which the host attempts to diminish the deleterious systemic effects of activated leukocytes during sepsis." @default.
• W1993925554 created "2016-06-24" @default.
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• W1993925554 date "2002-08-01" @default.
• W1993925554 modified "2023-09-25" @default.
• W1993925554 title "Soluble L-selectin attenuates tumor necrosis factor-α-mediated leukocyte adherence and vascular permeability: A protective role for elevated soluble L-selectin in sepsis*" @default.
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• W1993925554 doi "https://doi.org/10.1097/00003246-200208000-00028" @default.
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