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- W1993931991 abstract "We have identified a novel human gene, FEM1B, that encodes a protein virtually identical to that encoded by the mouse gene Fem1b. These mammalian proteins are homologs of the FEM-1 protein of Caenorhabditis elegans, which acts as a signal-transduction component within the nematode sex-determination pathway. We report here the mapping of FEM1B to chromosome 15q22, a region that is homologous to the region of mouse chromosome 9, where Fem1b resides. The BBS4 locus, one of the loci causing the autosomal recessive Bardet-Biedl syndrome, maps to this region of chromosome 15. Therefore, we sought to determine whether the FEM1B gene might be involved in this disorder. Radiation hybrid mapping demonstrates that FEM1B does not reside within the interval of chromosome 15 containing the BBS4 locus." @default.
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- W1993931991 date "2000-04-01" @default.
- W1993931991 modified "2023-09-23" @default.
- W1993931991 title "Rapid Communication: The Human FEMI B Gene Maps to Chromosome lSq22 and Is Excluded as the Gene for Bardet-Biedl Syndrome, Type 4" @default.
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- W1993931991 doi "https://doi.org/10.1016/s0002-9629(15)40743-8" @default.
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