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- W1993945707 abstract "Early embryogenesis in higher animals proceeds through a series of complex morphogenetic movements followed by intercellular communications sufficiently sophisticated that most groups of cells learn their positions and their fates before physical evidence for differentiation can be detected. It has been assumed that molecular events at the cell surface are initially responsible for the recognition and communication between cell and environment in these systems, but the nature of these molecular events has been totally obscure. This review presents the argument that recognition and communication may result from interactions between cell surface glycosyltransferases and their cell surface glycosyl acceptors. If two cells possess surfaces enzymes and appropriate substrates, and if these are prohibited from interacting with each other on a single cell surface, then enzyme-substrate binding will occur between these two cells when they make contact. This relationship would account for intercellular recognition. By controlling the availability of the necessary sugar donor or the required cation, cells could control the degree to which these complexes undergo catalysis. If catalysis should take place, then the cells will have changed each other's surface carbohydrates. This, in turn, could initiate intracellular changes and might account for communication. Evidence for this model comes from studies on normal and malignant cells in culture, adhesive recognition between embryonic cells, organ culture of embryonic tissues, whole embryos, platelet aggregation, and clearance of serum glycoproteins by the liver." @default.
- W1993945707 created "2016-06-24" @default.
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- W1993945707 date "1973-12-01" @default.
- W1993945707 modified "2023-09-26" @default.
- W1993945707 title "A Molecular Model for Cell Interactions" @default.
- W1993945707 doi "https://doi.org/10.1086/407816" @default.
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