FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993951917> ?p ?o ?g. }

• W1993951917 endingPage "162" @default.
• W1993951917 startingPage "156" @default.
• W1993951917 abstract "A cytochrome P-450 (P-450), designated P-450HKω, has been isolated and purified from human kidney microsomes to a specific content of 13 nmoles of P-450/mg of protein. P-450HKω showed an apparent molecular weight of 52,000 on sodium dodecyl sulfate-polyaerylamide gel electrophoresis (SDS-PAGE). Absolute spectra of the oxidized form indicated that this P-450 was largely in the low-spin state and partly in the high-spin state. It catalyzed the ω-and (ω − 1)-hydroxylation of fatty acids such as laurate, myristate, and palmitate, with no activity toward prostaglandin A1, benzphetamine, 7-ethoxycoumarin, or 7-ethoxyresorufin. The first 35 NH2-terminal amino acid sequence of P-450HKω had about 70% homology with those of rabbit kidney fatty acid ω-hydroxylases of the P-450 IVA gene subfamily, P-450ka-1, P-450ka-2, and P-450kd, except for four undetermined residues. Moreover, Western blot and immuno-inhibition studies showed that P-450HKω reacted with an antibody against the rabbit kidney fatty acid ω-hydroxylase. The results suggest that P-450HKω is a member of the same P-450 gene family (IVA subfamily) as the rabbit enzymes. In addition, the terminal sequence of P-450HKω also showed 54% homology with that of P-450k-2, a fatty acid ω-hydroxylase from rat kidney microsomes. To our knowledge, this is the first time that a P-450 specific for fatty acid ω-hydroxylase activity has been isolated to homogeneity from human tissues." @default.
• W1993951917 created "2016-06-24" @default.
• W1993951917 creator A5023252826 @default.
• W1993951917 creator A5027163096 @default.
• W1993951917 creator A5043617225 @default.
• W1993951917 creator A5056246935 @default.
• W1993951917 creator A5064147897 @default.
• W1993951917 date "1992-01-01" @default.
• W1993951917 modified "2023-09-27" @default.
• W1993951917 title "Purification and NH2-terminal amino acid sequences of human and rat kidney fatty acid ω-hydroxylases" @default.
• W1993951917 cites W1448935461 @default.
• W1993951917 cites W1484115349 @default.
• W1993951917 cites W1532212858 @default.
• W1993951917 cites W1560611582 @default.
• W1993951917 cites W1571327998 @default.
• W1993951917 cites W1581985454 @default.
• W1993951917 cites W1607574695 @default.
• W1993951917 cites W1689760343 @default.
• W1993951917 cites W1761340827 @default.
• W1993951917 cites W1806194750 @default.
• W1993951917 cites W1880695437 @default.
• W1993951917 cites W1899533542 @default.
• W1993951917 cites W1909277103 @default.
• W1993951917 cites W1968129594 @default.
• W1993951917 cites W1970976804 @default.
• W1993951917 cites W1971998745 @default.
• W1993951917 cites W2002622841 @default.
• W1993951917 cites W2013266148 @default.
• W1993951917 cites W2019934305 @default.
• W1993951917 cites W2035884940 @default.
• W1993951917 cites W2041689832 @default.
• W1993951917 cites W2052428509 @default.
• W1993951917 cites W2077710238 @default.
• W1993951917 cites W2084234371 @default.
• W1993951917 cites W2094948961 @default.
• W1993951917 cites W2096763509 @default.
• W1993951917 cites W2100837269 @default.
• W1993951917 cites W2112242501 @default.
• W1993951917 cites W2148767258 @default.
• W1993951917 cites W2410514936 @default.
• W1993951917 cites W4300724954 @default.
• W1993951917 cites W4323285379 @default.
• W1993951917 cites W981939111 @default.
• W1993951917 doi "https://doi.org/10.1016/0005-2760(92)90106-6" @default.
• W1993951917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1739747" @default.
• W1993951917 hasPublicationYear "1992" @default.
• W1993951917 type Work @default.
• W1993951917 sameAs 1993951917 @default.
• W1993951917 citedByCount "33" @default.
• W1993951917 countsByYear W19939519172018 @default.
• W1993951917 crossrefType "journal-article" @default.
• W1993951917 hasAuthorship W1993951917A5023252826 @default.
• W1993951917 hasAuthorship W1993951917A5027163096 @default.
• W1993951917 hasAuthorship W1993951917A5043617225 @default.
• W1993951917 hasAuthorship W1993951917A5056246935 @default.
• W1993951917 hasAuthorship W1993951917A5064147897 @default.
• W1993951917 hasConcept C104317684 @default.
• W1993951917 hasConcept C134018914 @default.
• W1993951917 hasConcept C153911025 @default.
• W1993951917 hasConcept C167625842 @default.
• W1993951917 hasConcept C181199279 @default.
• W1993951917 hasConcept C185592680 @default.
• W1993951917 hasConcept C2777606763 @default.
• W1993951917 hasConcept C2780091579 @default.
• W1993951917 hasConcept C2780768313 @default.
• W1993951917 hasConcept C2781003072 @default.
• W1993951917 hasConcept C2781109383 @default.
• W1993951917 hasConcept C515207424 @default.
• W1993951917 hasConcept C526171541 @default.
• W1993951917 hasConcept C543025807 @default.
• W1993951917 hasConcept C55493867 @default.
• W1993951917 hasConcept C86803240 @default.
• W1993951917 hasConcept C87644729 @default.
• W1993951917 hasConceptScore W1993951917C104317684 @default.
• W1993951917 hasConceptScore W1993951917C134018914 @default.
• W1993951917 hasConceptScore W1993951917C153911025 @default.
• W1993951917 hasConceptScore W1993951917C167625842 @default.
• W1993951917 hasConceptScore W1993951917C181199279 @default.
• W1993951917 hasConceptScore W1993951917C185592680 @default.
• W1993951917 hasConceptScore W1993951917C2777606763 @default.
• W1993951917 hasConceptScore W1993951917C2780091579 @default.
• W1993951917 hasConceptScore W1993951917C2780768313 @default.
• W1993951917 hasConceptScore W1993951917C2781003072 @default.
• W1993951917 hasConceptScore W1993951917C2781109383 @default.
• W1993951917 hasConceptScore W1993951917C515207424 @default.
• W1993951917 hasConceptScore W1993951917C526171541 @default.
• W1993951917 hasConceptScore W1993951917C543025807 @default.
• W1993951917 hasConceptScore W1993951917C55493867 @default.
• W1993951917 hasConceptScore W1993951917C86803240 @default.
• W1993951917 hasConceptScore W1993951917C87644729 @default.
• W1993951917 hasFunder F4320320912 @default.
• W1993951917 hasIssue "2" @default.
• W1993951917 hasLocation W19939519171 @default.
• W1993951917 hasLocation W19939519172 @default.
• W1993951917 hasOpenAccess W1993951917 @default.
• W1993951917 hasPrimaryLocation W19939519171 @default.
• W1993951917 hasRelatedWork W166915932 @default.
• W1993951917 hasRelatedWork W1982069143 @default.

• next