FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993962367> ?p ?o ?g. }

• W1993962367 endingPage "107" @default.
• W1993962367 startingPage "94" @default.
• W1993962367 abstract "Astrocytes react to brain injury triggering neuroinflammatory processes that determine the degree of neuronal damage. However, the signaling events associated to astrocyte activation remain largely undefined. The nuclear factor of activated T-cells (NFAT) is a transcription factor family implicated in activation of immune cells. We previously characterized the expression of NFAT isoforms in cultured astrocytes, and NFAT activation in response to mechanical lesion. Here we analyze NFATc3 in two mouse models of inflammatory brain damage: hippocampal excitotoxicity induced by intracerebral kainic acid (KA) injection and cortical mechanical lesion. Immunofluorescence results demonstrated that NFATc3 is specifically induced in a subset of reactive astrocytes, and not in microglia or neurons. In KA-treated brains, NFATc3 expression is transient and NFATc3-positive astrocytes concentrate around damaged neurons in areas CA3 and CA1. Complementary Western blot and RT-PCR analysis revealed an NFAT-dependent induction of RCAN1-4 and COX-2 in hippocampus as soon as 6 h after KA exposure, indicating that NFAT activation precedes NFATc3 over-expression. Moreover, activation of NFAT by ATP increased NFATc3 mRNA levels in astrocyte cultures, suggesting that NFATc3 expression is controlled through an auto-regulatory loop. Meanwhile, stab wound enhanced NFATc3 expression specifically in a subclass of reactive astrocytes confined within the proximal layer of the glial scar, and GFAP immunoreactivity was attenuated in NFATc3-expressing astrocytes. In conclusion, our work establishes NFATc3 as a marker of activation for a specific population of astrocytes in response to brain damage, which may have consequences for neuronal survival." @default.
• W1993962367 created "2016-06-24" @default.
• W1993962367 creator A5015102352 @default.
• W1993962367 creator A5030978055 @default.
• W1993962367 creator A5031585933 @default.
• W1993962367 creator A5033758787 @default.
• W1993962367 creator A5046228495 @default.
• W1993962367 creator A5076208035 @default.
• W1993962367 creator A5083968750 @default.
• W1993962367 date "2010-10-21" @default.
• W1993962367 modified "2023-10-02" @default.
• W1993962367 title "Response of transcription factor NFATc3 to excitotoxic and traumatic brain insults: Identification of a subpopulation of reactive astrocytes" @default.
• W1993962367 cites W1569503463 @default.
• W1993962367 cites W1573394911 @default.
• W1993962367 cites W1959673526 @default.
• W1993962367 cites W1962526731 @default.
• W1993962367 cites W1966418958 @default.
• W1993962367 cites W1967336595 @default.
• W1993962367 cites W1969133124 @default.
• W1993962367 cites W1974105812 @default.
• W1993962367 cites W1975483277 @default.
• W1993962367 cites W1981196417 @default.
• W1993962367 cites W1984899161 @default.
• W1993962367 cites W1986288029 @default.
• W1993962367 cites W1987863510 @default.
• W1993962367 cites W1988278010 @default.
• W1993962367 cites W1988581414 @default.
• W1993962367 cites W1991401817 @default.
• W1993962367 cites W1993220836 @default.
• W1993962367 cites W1993536160 @default.
• W1993962367 cites W1996243257 @default.
• W1993962367 cites W1998492387 @default.
• W1993962367 cites W2000129128 @default.
• W1993962367 cites W2001320540 @default.
• W1993962367 cites W2005629604 @default.
• W1993962367 cites W2005777709 @default.
• W1993962367 cites W2007598101 @default.
• W1993962367 cites W2007774889 @default.
• W1993962367 cites W2011553901 @default.
• W1993962367 cites W2014281284 @default.
• W1993962367 cites W2017372504 @default.
• W1993962367 cites W2028862182 @default.
• W1993962367 cites W2034981196 @default.
• W1993962367 cites W2046192706 @default.
• W1993962367 cites W2050382124 @default.
• W1993962367 cites W2050777200 @default.
• W1993962367 cites W2053010478 @default.
• W1993962367 cites W2054588014 @default.
• W1993962367 cites W2058830580 @default.
• W1993962367 cites W2059751541 @default.
• W1993962367 cites W2059830137 @default.
• W1993962367 cites W2067244940 @default.
• W1993962367 cites W2069072436 @default.
• W1993962367 cites W2073390876 @default.
• W1993962367 cites W2073580835 @default.
• W1993962367 cites W2074661552 @default.
• W1993962367 cites W2075845422 @default.
• W1993962367 cites W2079733602 @default.
• W1993962367 cites W2090956512 @default.
• W1993962367 cites W2098042360 @default.
• W1993962367 cites W2103037576 @default.
• W1993962367 cites W2107277218 @default.
• W1993962367 cites W2123292162 @default.
• W1993962367 cites W2123630494 @default.
• W1993962367 cites W2135086857 @default.
• W1993962367 cites W2143674877 @default.
• W1993962367 cites W2144967802 @default.
• W1993962367 cites W2147490295 @default.
• W1993962367 cites W2154889368 @default.
• W1993962367 cites W2157973267 @default.
• W1993962367 cites W2159721645 @default.
• W1993962367 cites W2159738116 @default.
• W1993962367 cites W2327006078 @default.
• W1993962367 doi "https://doi.org/10.1002/glia.21079" @default.
• W1993962367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20967884" @default.
• W1993962367 hasPublicationYear "2010" @default.
• W1993962367 type Work @default.
• W1993962367 sameAs 1993962367 @default.
• W1993962367 citedByCount "39" @default.
• W1993962367 countsByYear W19939623672012 @default.
• W1993962367 countsByYear W19939623672013 @default.
• W1993962367 countsByYear W19939623672014 @default.
• W1993962367 countsByYear W19939623672015 @default.
• W1993962367 countsByYear W19939623672016 @default.
• W1993962367 countsByYear W19939623672017 @default.
• W1993962367 countsByYear W19939623672018 @default.
• W1993962367 countsByYear W19939623672019 @default.
• W1993962367 countsByYear W19939623672020 @default.
• W1993962367 countsByYear W19939623672021 @default.
• W1993962367 countsByYear W19939623672022 @default.
• W1993962367 countsByYear W19939623672023 @default.
• W1993962367 crossrefType "journal-article" @default.
• W1993962367 hasAuthorship W1993962367A5015102352 @default.
• W1993962367 hasAuthorship W1993962367A5030978055 @default.
• W1993962367 hasAuthorship W1993962367A5031585933 @default.
• W1993962367 hasAuthorship W1993962367A5033758787 @default.
• W1993962367 hasAuthorship W1993962367A5046228495 @default.
• W1993962367 hasAuthorship W1993962367A5076208035 @default.

• next