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- W1993967721 abstract "Currently, clinical and experimental evidence point to an essential role of estrogens and estrogen receptors in male fertility. The expression of estrogen receptor α (ERα) and β (ERβ) in human testis has been described. However, some studies were unable to detect ERα, while others report the expression of both isoforms, with ERβ presenting a wide distribution within somatic and germinal testicular cells. This has suggested that estrogens may exert their testicular effects exclusively through ERβ. The present work aims to study the expression of ERα and ERβ in testicular biopsies of men with conserved and disrupted spermatogenesis, in order to better clarify the positive cell populations. Human testicular tissue was obtained from 10 men undergoing testicular biopsy for infertility relief due to azoospermia: two patients had secondary obstructive azoospermia with conserved spermatogenesis, five had Sertoli cell-only syndrome, two had hypospermatogenesis and one had meiotic arrest. Reverse-transcription polymerase chain reaction (RT-PCR) allowed the detection of both ERα and ERβ mRNAs in all samples. Immunohistochemistry revealed that ERα was present in Leydig cells, Sertoli cells, spermatogonia, spermatocytes, round spermatids and elongated spermatids/spermatozoa, while ERβ was present in the same cell types except spermatogonia and Sertoli cells. This study demonstrates ERα mRNA expression in human testis and describes its localization in somatic and germ cell subtypes. These findings suggest that both ER isoforms are involved in the control of testicular function." @default.
- W1993967721 created "2016-06-24" @default.
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- W1993967721 date "2009-01-01" @default.
- W1993967721 modified "2023-10-17" @default.
- W1993967721 title "Estrogen Receptors α and β in Human Testis: Both Isoforms are Expressed" @default.
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- W1993967721 doi "https://doi.org/10.3109/19396360902855733" @default.
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