FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993978935> ?p ?o ?g. }

• W1993978935 endingPage "593" @default.
• W1993978935 startingPage "585" @default.
• W1993978935 abstract "Over the course of development, the vertebrate heart undergoes a series of complex morphogenetic processes that transforms it from a simple myocardial epithelium to the complex 3D structure required for its function. One of these processes leads to the formation of trabeculae to optimize the internal structure of the ventricle for efficient conduction and contraction. Despite the important role of trabeculae in the development and physiology of the heart, little is known about their mechanism of formation. Using 3D time-lapse imaging of beating zebrafish hearts, we observed that the initiation of cardiac trabeculation can be divided into two processes. Before any myocardial cell bodies have entered the trabecular layer, cardiomyocytes extend protrusions that invade luminally along neighboring cell-cell junctions. These protrusions can interact within the trabecular layer to form new cell-cell contacts. Subsequently, cardiomyocytes constrict their abluminal surface, moving their cell bodies into the trabecular layer while elaborating more protrusions. We also examined the formation of these protrusions in trabeculation-deficient animals, including erbb2 mutants, tnnt2a morphants, which lack cardiac contractions and flow, and myh6 morphants, which lack atrial contraction and exhibit reduced flow. We found that, compared with cardiomyocytes in wild-type hearts, those in erbb2 mutants were less likely to form protrusions, those in tnnt2a morphants formed less stable protrusions, and those in myh6 morphants extended fewer protrusions per cell. Thus, through detailed 4D imaging of beating hearts, we have identified novel cellular behaviors underlying cardiac trabeculation." @default.
• W1993978935 created "2016-06-24" @default.
• W1993978935 creator A5005112936 @default.
• W1993978935 creator A5019141100 @default.
• W1993978935 creator A5021100088 @default.
• W1993978935 creator A5028481056 @default.
• W1993978935 creator A5089780494 @default.
• W1993978935 creator A5091230718 @default.
• W1993978935 date "2014-02-01" @default.
• W1993978935 modified "2023-10-12" @default.
• W1993978935 title "High-resolution imaging of cardiomyocyte behavior reveals two distinct steps in ventricular trabeculation" @default.
• W1993978935 cites W1540070193 @default.
• W1993978935 cites W1963577861 @default.
• W1993978935 cites W1973018632 @default.
• W1993978935 cites W1973647878 @default.
• W1993978935 cites W1973706332 @default.
• W1993978935 cites W1975523864 @default.
• W1993978935 cites W1980141913 @default.
• W1993978935 cites W1981956570 @default.
• W1993978935 cites W1982210988 @default.
• W1993978935 cites W1996648013 @default.
• W1993978935 cites W1998342517 @default.
• W1993978935 cites W2000647402 @default.
• W1993978935 cites W2009476579 @default.
• W1993978935 cites W2016010426 @default.
• W1993978935 cites W2024470896 @default.
• W1993978935 cites W2027000467 @default.
• W1993978935 cites W2029402099 @default.
• W1993978935 cites W2034887388 @default.
• W1993978935 cites W2035536816 @default.
• W1993978935 cites W2038600043 @default.
• W1993978935 cites W2040795905 @default.
• W1993978935 cites W2044679605 @default.
• W1993978935 cites W2053679951 @default.
• W1993978935 cites W2053680680 @default.
• W1993978935 cites W2055720955 @default.
• W1993978935 cites W2059519946 @default.
• W1993978935 cites W2066888615 @default.
• W1993978935 cites W2069433703 @default.
• W1993978935 cites W2083671963 @default.
• W1993978935 cites W2087065964 @default.
• W1993978935 cites W2088703231 @default.
• W1993978935 cites W2096132763 @default.
• W1993978935 cites W2099259128 @default.
• W1993978935 cites W2100164332 @default.
• W1993978935 cites W2109123354 @default.
• W1993978935 cites W2111338477 @default.
• W1993978935 cites W2114139217 @default.
• W1993978935 cites W2116039818 @default.
• W1993978935 cites W2116371846 @default.
• W1993978935 cites W2123924700 @default.
• W1993978935 cites W2127367210 @default.
• W1993978935 cites W2128316931 @default.
• W1993978935 cites W2132947942 @default.
• W1993978935 cites W2139645646 @default.
• W1993978935 cites W2139979516 @default.
• W1993978935 cites W2144147853 @default.
• W1993978935 cites W2144328065 @default.
• W1993978935 cites W2145434546 @default.
• W1993978935 cites W2150627711 @default.
• W1993978935 cites W2151153556 @default.
• W1993978935 cites W2156743286 @default.
• W1993978935 cites W2157408682 @default.
• W1993978935 cites W2167279371 @default.
• W1993978935 doi "https://doi.org/10.1242/dev.098632" @default.
• W1993978935 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3899815" @default.
• W1993978935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24401373" @default.
• W1993978935 hasPublicationYear "2014" @default.
• W1993978935 type Work @default.
• W1993978935 sameAs 1993978935 @default.
• W1993978935 citedByCount "110" @default.
• W1993978935 countsByYear W19939789352014 @default.
• W1993978935 countsByYear W19939789352015 @default.
• W1993978935 countsByYear W19939789352016 @default.
• W1993978935 countsByYear W19939789352017 @default.
• W1993978935 countsByYear W19939789352018 @default.
• W1993978935 countsByYear W19939789352019 @default.
• W1993978935 countsByYear W19939789352020 @default.
• W1993978935 countsByYear W19939789352021 @default.
• W1993978935 countsByYear W19939789352022 @default.
• W1993978935 countsByYear W19939789352023 @default.
• W1993978935 crossrefType "journal-article" @default.
• W1993978935 hasAuthorship W1993978935A5005112936 @default.
• W1993978935 hasAuthorship W1993978935A5019141100 @default.
• W1993978935 hasAuthorship W1993978935A5021100088 @default.
• W1993978935 hasAuthorship W1993978935A5028481056 @default.
• W1993978935 hasAuthorship W1993978935A5089780494 @default.
• W1993978935 hasAuthorship W1993978935A5091230718 @default.
• W1993978935 hasBestOaLocation W19939789351 @default.
• W1993978935 hasConcept C104317684 @default.
• W1993978935 hasConcept C105702510 @default.
• W1993978935 hasConcept C126322002 @default.
• W1993978935 hasConcept C145103041 @default.
• W1993978935 hasConcept C207200792 @default.
• W1993978935 hasConcept C2776878037 @default.
• W1993978935 hasConcept C2777837822 @default.
• W1993978935 hasConcept C2778921608 @default.
• W1993978935 hasConcept C40692019 @default.

• next