Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993987223> ?p ?o ?g. }
- W1993987223 endingPage "312" @default.
- W1993987223 startingPage "298" @default.
- W1993987223 abstract "Neurodegenerative diseases such as Parkinson's, Alzheimer's, and prion diseases have at least three common denominators: (i) progressive loss of neuron function, which leads to cognitive decline; (ii) the molecular basis of the disease, which involves metalloprotein misfolding and aggregation (amyloid beta, alpha synuclein, and prion protein), or metal ion (Cu2+, Zn2+, and Fe3+) imbalances that result in oxidative stress; and (iii) the current lack of a therapy to reverse or stop the progression of symptoms. These problems are discussed collectively in the present review. First, the molecular bases of these three diseases are explained in brief, with a special focus on the role of coordination chemistry in each case. Next, several commercial drugs that can be used to treat the symptoms are presented, i.e., those that do not aim to achieve metal ion homeostasis, which may be less well known in the bioinorganic community; and those that aim to achieve metal ion chelation, including the molecular scaffolds of those currently in clinical trials and the most promising targets that are still being studied in vitro. Another very important issue summarized in this review encompasses the strategies that have been developed to overcome the blood–brain barrier (BBB) and deliver drugs inside the brain. The BBB is a major obstacle in the development of drugs for treating central nervous system diseases. The BBB includes anatomical, physicochemical, and biochemical mechanisms that control the exchange of molecules between the blood and brain, thereby making the BBB virtually impermeable to drugs that might be used to treat neurodegenerative diseases. The non-optimistic nature of this review has a dual role. First, we present a true picture of the progress in the development of potential therapeutics. Second, we aim to encourage further targeted research in this area." @default.
- W1993987223 created "2016-06-24" @default.
- W1993987223 creator A5050708434 @default.
- W1993987223 creator A5065855691 @default.
- W1993987223 creator A5072611843 @default.
- W1993987223 date "2015-02-01" @default.
- W1993987223 modified "2023-10-08" @default.
- W1993987223 title "Neurodegenerative diseases – Understanding their molecular bases and progress in the development of potential treatments" @default.
- W1993987223 cites W1538748480 @default.
- W1993987223 cites W1557182452 @default.
- W1993987223 cites W1561072761 @default.
- W1993987223 cites W1576911364 @default.
- W1993987223 cites W1599715713 @default.
- W1993987223 cites W1602771322 @default.
- W1993987223 cites W1704732331 @default.
- W1993987223 cites W1864253247 @default.
- W1993987223 cites W1963712466 @default.
- W1993987223 cites W1964081428 @default.
- W1993987223 cites W1964717067 @default.
- W1993987223 cites W1965556778 @default.
- W1993987223 cites W1965739481 @default.
- W1993987223 cites W1966902515 @default.
- W1993987223 cites W1967464880 @default.
- W1993987223 cites W1968214306 @default.
- W1993987223 cites W1968664475 @default.
- W1993987223 cites W1968830969 @default.
- W1993987223 cites W1969868345 @default.
- W1993987223 cites W1970159001 @default.
- W1993987223 cites W1970949382 @default.
- W1993987223 cites W1972279798 @default.
- W1993987223 cites W1973485004 @default.
- W1993987223 cites W1975802239 @default.
- W1993987223 cites W1976219141 @default.
- W1993987223 cites W1979833383 @default.
- W1993987223 cites W1981471614 @default.
- W1993987223 cites W1983546909 @default.
- W1993987223 cites W1984727011 @default.
- W1993987223 cites W1986303437 @default.
- W1993987223 cites W1987566729 @default.
- W1993987223 cites W1989277130 @default.
- W1993987223 cites W1990473626 @default.
- W1993987223 cites W1991039509 @default.
- W1993987223 cites W1992883702 @default.
- W1993987223 cites W1994310450 @default.
- W1993987223 cites W1994939101 @default.
- W1993987223 cites W1996941571 @default.
- W1993987223 cites W2000262724 @default.
- W1993987223 cites W2001525797 @default.
- W1993987223 cites W2002728772 @default.
- W1993987223 cites W2002781682 @default.
- W1993987223 cites W2003736464 @default.
- W1993987223 cites W2005693512 @default.
- W1993987223 cites W2006961468 @default.
- W1993987223 cites W2007134309 @default.
- W1993987223 cites W2007157911 @default.
- W1993987223 cites W2008149491 @default.
- W1993987223 cites W2008657049 @default.
- W1993987223 cites W2010298069 @default.
- W1993987223 cites W2010363474 @default.
- W1993987223 cites W2010415721 @default.
- W1993987223 cites W2011668168 @default.
- W1993987223 cites W2011817526 @default.
- W1993987223 cites W2012128918 @default.
- W1993987223 cites W2013363580 @default.
- W1993987223 cites W2013495726 @default.
- W1993987223 cites W2013679718 @default.
- W1993987223 cites W2013801677 @default.
- W1993987223 cites W2014206803 @default.
- W1993987223 cites W2014500031 @default.
- W1993987223 cites W2014763774 @default.
- W1993987223 cites W2017550829 @default.
- W1993987223 cites W2018123347 @default.
- W1993987223 cites W2018362863 @default.
- W1993987223 cites W2018974184 @default.
- W1993987223 cites W2019845065 @default.
- W1993987223 cites W2021989110 @default.
- W1993987223 cites W2023712994 @default.
- W1993987223 cites W2023918463 @default.
- W1993987223 cites W2026041796 @default.
- W1993987223 cites W2026466464 @default.
- W1993987223 cites W2026676471 @default.
- W1993987223 cites W2027207072 @default.
- W1993987223 cites W2027313353 @default.
- W1993987223 cites W2028235489 @default.
- W1993987223 cites W2028267884 @default.
- W1993987223 cites W2029246446 @default.
- W1993987223 cites W2030927274 @default.
- W1993987223 cites W2032392617 @default.
- W1993987223 cites W2032468019 @default.
- W1993987223 cites W2033653810 @default.
- W1993987223 cites W2035063280 @default.
- W1993987223 cites W2035899248 @default.
- W1993987223 cites W2037441494 @default.
- W1993987223 cites W2037699200 @default.
- W1993987223 cites W2039910652 @default.
- W1993987223 cites W2040364087 @default.
- W1993987223 cites W2043732645 @default.
- W1993987223 cites W2044657849 @default.