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• W1993989509 abstract "In search for a novel chemotype to develop topoisomerase I (Top1) inhibitors, the pyrazolo[1,5-a]quinazoline nucleus, structurally related to the indenoisoquinoline system precursor of well-known Top1 poisons, was variously decorated (i.e., a substituted phenyl ring at 2- or 3-position, a protonable side chain at 4- or 5-position), affording a number of Top1 inhibitors with cleavage patterns common to CPT and MJ-III-65. SARs data were rationalized by means of an advanced docking protocol." @default.
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• W1993989509 date "2013-09-16" @default.
• W1993989509 modified "2023-09-25" @default.
• W1993989509 title "Phenylpyrazolo[1,5-<i>a</i>]quinazolin-5(4<i>H</i>)-one: A Suitable Scaffold for the Development of Noncamptothecin Topoisomerase I (Top1) Inhibitors" @default.
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• W1993989509 doi "https://doi.org/10.1021/jm400932c" @default.
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