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- W1993996978 abstract "It has been nearly 20 years since the initial discoveries of catalytic RNAs. The first demonstrated catalytic RNAs, or ribozymes, were derived from the intron of the Tetrahymena large (26S) rRNA subunit[ 1 Kruger K. et al. Cell. 1982; 31: 147-157 Abstract Full Text PDF PubMed Scopus (1550) Google Scholar ]and the RNA component of Escherichia coli RNAse P (Ref. [ 2 Guerrier-Takada C. et al. Cell. 1983; 35: 849-869 Abstract Full Text PDF PubMed Scopus (2015) Google Scholar ]). The Tetrahymena intron was shown to catalyse a two-step trans-esterification reaction resulting in joining of the two rRNA exons and release of the intron. The RNA subunit of E. coli RNAse P was demonstrated to be capable of cleaving the 5′ leader segment from precursor transfer RNAs. The Tetrahymena intron is one member of a large family of introns termed group I, which is classified by common structural and sequence motifs[ 3 Jaeger, L., Michel, F. and Westhof, E. (1996) in Nucleic Acids and Molecular Biology (Vol. 10) (Eckstein, F. and Lilley, D.M.J., eds), pp. 33–51, Springer-Verlag Google Scholar ]. Many, but not all, of these are capable of catalysing self-splicing reactions. Subsequent to the discoveries of group I and RNAse P catalytic RNAs, five other ribozyme motifs have been characterized, and these are found throughout bacteria, fungi, plants and vertebrates[ 4 Rossi, J.J. (1998) in Applied Antisense Oligonucleotide Technology (Stein, C.A. and Krieg, A.M., eds), pp. 511–525, Wiley-Liss Google Scholar ]." @default.
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- W1993996978 date "1998-12-01" @default.
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- W1993996978 title "Ribozymes to the rescue: repairing genetically defective mRNAs" @default.
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- W1993996978 doi "https://doi.org/10.1016/s0168-9525(98)01530-3" @default.
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