Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994005296> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1994005296 endingPage "1491" @default.
- W1994005296 startingPage "1488" @default.
- W1994005296 abstract "Background —Tests developed to monitor glycoprotein (GP) IIb/IIIa blockade do not properly reflect platelet function in vivo and need a baseline (pretreatment) value. Because GP IIb/IIIa is essential in platelet aggregation and thrombosis under shear conditions, a flow-dependent approach to monitor its inhibition can be used. Methods and Results —We compared a test based on flow-dependent platelet deposition, the Cone and Platelet Analyzer (CPA), with in vitro platelet aggregometry and the Rapid Platelet Function Assay (RPFA) on platelet function after GP IIb/IIIa inhibition. In vitro, increasing concentrations of abciximab (0% to 100% receptor occupancy) were tested. Ex vivo, platelet function was monitored with the CPA and with aggregometry for up to 1 week after abciximab administration. The CPA was better correlated with the percentage of free GP IIb/IIIa receptors than was aggregometry or the RPFA. Only the RPFA, when expressed as a ratio over baseline (pretreatment), was comparable to the CPA. Ex vivo, the CPA, but not aggregometry, showed prolonged platelet inhibition with gradual recovery from GP IIb/IIIa receptor blockade in the first week after abciximab administration. Conclusions —Platelet function assessment by shear-induced deposition is a reliable test to monitor a wide range of GP IIb/IIIa inhibition. Its accuracy does not require a baseline reference. The effects of GP IIb/IIIa blockade on platelet function should be examined under high shear conditions." @default.
- W1994005296 created "2016-06-24" @default.
- W1994005296 creator A5011306771 @default.
- W1994005296 creator A5015559144 @default.
- W1994005296 creator A5025226122 @default.
- W1994005296 creator A5033933251 @default.
- W1994005296 creator A5043010855 @default.
- W1994005296 creator A5050858268 @default.
- W1994005296 creator A5073029210 @default.
- W1994005296 creator A5085697970 @default.
- W1994005296 creator A5090962770 @default.
- W1994005296 date "2001-03-20" @default.
- W1994005296 modified "2023-09-23" @default.
- W1994005296 title "Testing Platelet Activation With a Shear-Dependent Platelet Function Test Versus Aggregation-Based Tests" @default.
- W1994005296 cites W122479260 @default.
- W1994005296 cites W1987892547 @default.
- W1994005296 cites W2046308564 @default.
- W1994005296 cites W2101951362 @default.
- W1994005296 doi "https://doi.org/10.1161/01.cir.103.11.1488" @default.
- W1994005296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11257073" @default.
- W1994005296 hasPublicationYear "2001" @default.
- W1994005296 type Work @default.
- W1994005296 sameAs 1994005296 @default.
- W1994005296 citedByCount "43" @default.
- W1994005296 countsByYear W19940052962013 @default.
- W1994005296 countsByYear W19940052962014 @default.
- W1994005296 countsByYear W19940052962016 @default.
- W1994005296 countsByYear W19940052962021 @default.
- W1994005296 crossrefType "journal-article" @default.
- W1994005296 hasAuthorship W1994005296A5011306771 @default.
- W1994005296 hasAuthorship W1994005296A5015559144 @default.
- W1994005296 hasAuthorship W1994005296A5025226122 @default.
- W1994005296 hasAuthorship W1994005296A5033933251 @default.
- W1994005296 hasAuthorship W1994005296A5043010855 @default.
- W1994005296 hasAuthorship W1994005296A5050858268 @default.
- W1994005296 hasAuthorship W1994005296A5073029210 @default.
- W1994005296 hasAuthorship W1994005296A5085697970 @default.
- W1994005296 hasAuthorship W1994005296A5090962770 @default.
- W1994005296 hasBestOaLocation W19940052961 @default.
- W1994005296 hasConcept C126322002 @default.
- W1994005296 hasConcept C150903083 @default.
- W1994005296 hasConcept C1621761 @default.
- W1994005296 hasConcept C207001950 @default.
- W1994005296 hasConcept C26291073 @default.
- W1994005296 hasConcept C26828662 @default.
- W1994005296 hasConcept C2777871224 @default.
- W1994005296 hasConcept C2910542480 @default.
- W1994005296 hasConcept C3018697912 @default.
- W1994005296 hasConcept C45393284 @default.
- W1994005296 hasConcept C500558357 @default.
- W1994005296 hasConcept C71924100 @default.
- W1994005296 hasConcept C86803240 @default.
- W1994005296 hasConcept C89560881 @default.
- W1994005296 hasConcept C98274493 @default.
- W1994005296 hasConceptScore W1994005296C126322002 @default.
- W1994005296 hasConceptScore W1994005296C150903083 @default.
- W1994005296 hasConceptScore W1994005296C1621761 @default.
- W1994005296 hasConceptScore W1994005296C207001950 @default.
- W1994005296 hasConceptScore W1994005296C26291073 @default.
- W1994005296 hasConceptScore W1994005296C26828662 @default.
- W1994005296 hasConceptScore W1994005296C2777871224 @default.
- W1994005296 hasConceptScore W1994005296C2910542480 @default.
- W1994005296 hasConceptScore W1994005296C3018697912 @default.
- W1994005296 hasConceptScore W1994005296C45393284 @default.
- W1994005296 hasConceptScore W1994005296C500558357 @default.
- W1994005296 hasConceptScore W1994005296C71924100 @default.
- W1994005296 hasConceptScore W1994005296C86803240 @default.
- W1994005296 hasConceptScore W1994005296C89560881 @default.
- W1994005296 hasConceptScore W1994005296C98274493 @default.
- W1994005296 hasIssue "11" @default.
- W1994005296 hasLocation W19940052961 @default.
- W1994005296 hasLocation W19940052962 @default.
- W1994005296 hasLocation W19940052963 @default.
- W1994005296 hasOpenAccess W1994005296 @default.
- W1994005296 hasPrimaryLocation W19940052961 @default.
- W1994005296 hasRelatedWork W1970063103 @default.
- W1994005296 hasRelatedWork W1972210545 @default.
- W1994005296 hasRelatedWork W1994005296 @default.
- W1994005296 hasRelatedWork W2013765863 @default.
- W1994005296 hasRelatedWork W2021145671 @default.
- W1994005296 hasRelatedWork W2077772721 @default.
- W1994005296 hasRelatedWork W2155132655 @default.
- W1994005296 hasRelatedWork W2165265464 @default.
- W1994005296 hasRelatedWork W2205535475 @default.
- W1994005296 hasRelatedWork W2279888260 @default.
- W1994005296 hasVolume "103" @default.
- W1994005296 isParatext "false" @default.
- W1994005296 isRetracted "false" @default.
- W1994005296 magId "1994005296" @default.
- W1994005296 workType "article" @default.