Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994008889> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1994008889 endingPage "540" @default.
- W1994008889 startingPage "537" @default.
- W1994008889 abstract "OBJECTIVE To examine the voiding behaviour changes in rats with bladder outlet obstruction (BOO) while inhibiting matrix metalloproteinase (MMP) activity with doxycycline, as increased MMP activity may be involved in obstruction‐induced bladder hypertrophy. MATERIALS AND METHODS Female Sprague‐Dawley were divided into eight groups (three rats in each group): normal control (NC) ± doxycycline, 3 weeks partial BOO (3WPBOO) ± doxycycline, 6 weeks PBOO ± doxycycline, and 3 weeks PBOO followed by 3 weeks de‐obstruction (3WOD) ± doxycycline. All rats received the same food and water and were on the same 12 h dark/light cycle housed in metabolic cages. Treatment groups were given doxycycline 15 mg/kg/day subcutaneously twice daily. The voiding variables measured were average voided volume (AV V) and voiding frequency (VF) in 24 h. After completion of the voiding behaviour studies, the rats were killed and their bladders were excised and weighed. RESULTS The AV Vs were significantly increased ( P < 0.05) in all study groups compared with the NC group except for the 3WPBOO‐doxycycline and 3WOD‐doxycycline groups. The VF was significantly increased ( P < 0.05) only in the 3WOD‐doxycycline group. The bladder weights were significantly increased after PBOO in all the study groups ( P < 0.05), except for the 3WOD group. CONCLUSION These data show that MMP inhibition may affect voiding behaviour during the response to BOO or its relief. This is the first clinical demonstration that interfering with a principal target of bladder muscle wall remodelling may have a direct effect on bladder function." @default.
- W1994008889 created "2016-06-24" @default.
- W1994008889 creator A5011107887 @default.
- W1994008889 creator A5058595095 @default.
- W1994008889 creator A5076191169 @default.
- W1994008889 creator A5078150047 @default.
- W1994008889 date "2009-02-01" @default.
- W1994008889 modified "2023-10-17" @default.
- W1994008889 title "Effects of doxycycline on voiding behaviour of rats with bladder outlet obstruction" @default.
- W1994008889 cites W1484891484 @default.
- W1994008889 cites W1975365640 @default.
- W1994008889 cites W1988102087 @default.
- W1994008889 cites W1995622858 @default.
- W1994008889 cites W1995962565 @default.
- W1994008889 cites W1999186101 @default.
- W1994008889 cites W2022421224 @default.
- W1994008889 cites W2037023762 @default.
- W1994008889 cites W2039724731 @default.
- W1994008889 cites W2059601601 @default.
- W1994008889 cites W2076144140 @default.
- W1994008889 cites W2076384592 @default.
- W1994008889 cites W2080581939 @default.
- W1994008889 cites W2102087112 @default.
- W1994008889 cites W2109627870 @default.
- W1994008889 cites W2120208564 @default.
- W1994008889 cites W2127624074 @default.
- W1994008889 cites W2211178889 @default.
- W1994008889 cites W2418352979 @default.
- W1994008889 cites W4293418087 @default.
- W1994008889 cites W4297819262 @default.
- W1994008889 doi "https://doi.org/10.1111/j.1464-410x.2008.08131.x" @default.
- W1994008889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18990141" @default.
- W1994008889 hasPublicationYear "2009" @default.
- W1994008889 type Work @default.
- W1994008889 sameAs 1994008889 @default.
- W1994008889 citedByCount "8" @default.
- W1994008889 countsByYear W19940088892013 @default.
- W1994008889 countsByYear W19940088892014 @default.
- W1994008889 countsByYear W19940088892015 @default.
- W1994008889 countsByYear W19940088892016 @default.
- W1994008889 countsByYear W19940088892020 @default.
- W1994008889 countsByYear W19940088892021 @default.
- W1994008889 crossrefType "journal-article" @default.
- W1994008889 hasAuthorship W1994008889A5011107887 @default.
- W1994008889 hasAuthorship W1994008889A5058595095 @default.
- W1994008889 hasAuthorship W1994008889A5076191169 @default.
- W1994008889 hasAuthorship W1994008889A5078150047 @default.
- W1994008889 hasConcept C109523444 @default.
- W1994008889 hasConcept C121608353 @default.
- W1994008889 hasConcept C126322002 @default.
- W1994008889 hasConcept C126894567 @default.
- W1994008889 hasConcept C141071460 @default.
- W1994008889 hasConcept C2776235491 @default.
- W1994008889 hasConcept C2777179404 @default.
- W1994008889 hasConcept C2779522043 @default.
- W1994008889 hasConcept C2780070792 @default.
- W1994008889 hasConcept C501593827 @default.
- W1994008889 hasConcept C71924100 @default.
- W1994008889 hasConcept C86803240 @default.
- W1994008889 hasConcept C89423630 @default.
- W1994008889 hasConceptScore W1994008889C109523444 @default.
- W1994008889 hasConceptScore W1994008889C121608353 @default.
- W1994008889 hasConceptScore W1994008889C126322002 @default.
- W1994008889 hasConceptScore W1994008889C126894567 @default.
- W1994008889 hasConceptScore W1994008889C141071460 @default.
- W1994008889 hasConceptScore W1994008889C2776235491 @default.
- W1994008889 hasConceptScore W1994008889C2777179404 @default.
- W1994008889 hasConceptScore W1994008889C2779522043 @default.
- W1994008889 hasConceptScore W1994008889C2780070792 @default.
- W1994008889 hasConceptScore W1994008889C501593827 @default.
- W1994008889 hasConceptScore W1994008889C71924100 @default.
- W1994008889 hasConceptScore W1994008889C86803240 @default.
- W1994008889 hasConceptScore W1994008889C89423630 @default.
- W1994008889 hasIssue "4" @default.
- W1994008889 hasLocation W19940088891 @default.
- W1994008889 hasLocation W19940088892 @default.
- W1994008889 hasOpenAccess W1994008889 @default.
- W1994008889 hasPrimaryLocation W19940088891 @default.
- W1994008889 hasRelatedWork W16064288 @default.
- W1994008889 hasRelatedWork W1970961371 @default.
- W1994008889 hasRelatedWork W2024096347 @default.
- W1994008889 hasRelatedWork W2039478507 @default.
- W1994008889 hasRelatedWork W2290409545 @default.
- W1994008889 hasRelatedWork W2370768546 @default.
- W1994008889 hasRelatedWork W2376776057 @default.
- W1994008889 hasRelatedWork W2580251150 @default.
- W1994008889 hasRelatedWork W4320483807 @default.
- W1994008889 hasRelatedWork W3141601932 @default.
- W1994008889 hasVolume "103" @default.
- W1994008889 isParatext "false" @default.
- W1994008889 isRetracted "false" @default.
- W1994008889 magId "1994008889" @default.
- W1994008889 workType "article" @default.