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- W1994017024 endingPage "714" @default.
- W1994017024 startingPage "714" @default.
- W1994017024 abstract "Introduction Few biological agents have received more attention than histamine during the past half-century. This simple chemical was synthesized in 1907 by Windaus and Vogt,1and was soon identified as a potent pharmacologic agent.2,3Although histamine is now well recognized as a normal intracellular constituent of many body tissues, years of study were required to establish this fact. Potent vasodilator substances were extractable from animal tissues, but the identity of any with histamine was difficult to prove.4Two decades of research were required to establish the importance of intracellular histamine and the physiological significance of its release. Of note were the classical observations of Thomas Lewis on the whealing response in human skin5and the studies by H. H. Dale on cellular histamine so nicely described in his Croonian lectures of 1929.6Dale suggested that antigen-antibody reactions might release histamine, but he also emphasized the many differences between the" @default.
- W1994017024 created "2016-06-24" @default.
- W1994017024 creator A5017886481 @default.
- W1994017024 date "1960-11-01" @default.
- W1994017024 modified "2023-09-24" @default.
- W1994017024 title "The Metabolism and Functions of Histamine" @default.
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