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• W19940216 abstract "The symptoms and pathology of viral diseases are characterized by direct effects of the viruses on their host cells, leading to death of the cells in some cases but more frequently to functional impairment. In some viral diseases, the antiviral immune response significantly contributes to disease symptoms and tissue damage by hypersensitivity reactions of types I through IV. This paper deals with an additional mechanism of viral pathogenesis, referred to as “autotoxicity”. This mechanisms is characterized by activation of host effector functions in the absence of a specific antiviral immune response. Influenza in mice is associated with enhanced generation of reactive oxygen species by phagocytes and by xanthine oxidase. In addition, a wide array of cytokines are detected in alveolar lavage fluid obtained from infected lungs. Collectively, the changes observed in murine influenza, and also in other viral diseases, e.g. AIDS, indicate that infection leads to oxidative stress. Antioxidants may find a place in the therapy of viral diseases in protecting against the harmful effects of oxidants. But the beneficial role of oxidants in the killing of microorganisms as well as the complex role of oxidants in metabolic regulation suggest that antioxidant therapy should be monitored carefully. The effect of antioxidant therapy could be enhanced by drugs that interfere with other pathways and mechanisms activated by viruses. Examples of possibly useful drugs include antagonists of platelet activating factor, inhibitors of lipoxygenase and nitric oxide synthase, and drugs that modulate the release and effects of certain cytokines such as tumor necrosis factor." @default.
• W19940216 created "2016-06-24" @default.
• W19940216 creator A5082260150 @default.
• W19940216 date "1994-01-01" @default.
• W19940216 modified "2023-09-25" @default.
• W19940216 title "Reactive oxygen, antioxidants, and autotoxicity in viral diseases" @default.
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• W19940216 doi "https://doi.org/10.1007/978-3-0348-7424-3_19" @default.
• W19940216 hasPublicationYear "1994" @default.
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