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• W1994043530 abstract "The crystallographic phase problem [Muirhead & Perutz (1963), Nature (London), 199, 633–638] remains the single major impediment to obtaining a three-dimensional structure of a macromolecule once suitable crystals have been obtained. Recently, it was found that it was possible to solve the structure of a 142-nucleotide L1 ligase ribozyme heterodimer that possesses no noncrystallographic symmetry without heavy-atom derivatives, anomalous scattering atoms or other modifications and without a model of the tertiary structure of the ribozyme [Robertson & Scott (2007), Science, 315, 1549–1553]. Using idealized known RNA secondary-structural fragments such as A-form helices and GNRA tetraloops in an iterative molecular-replacement procedure, it was possible to obtain an estimated phase set that, when subjected to solvent flattening, yielded an interpretable electron-density map with minimized model bias, allowing the tertiary structure of the ribozyme to be solved. This approach has also proven successful with other ribozymes, structured RNAs and RNA–protein complexes." @default.
• W1994043530 created "2016-06-24" @default.
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• W1994043530 date "2008-06-18" @default.
• W1994043530 modified "2023-09-26" @default.
• W1994043530 title "A general method for phasing novel complex RNA crystal structures without heavy-atom derivatives" @default.
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• W1994043530 doi "https://doi.org/10.1107/s0907444908011578" @default.
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