FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994043834> ?p ?o ?g. }

• W1994043834 endingPage "E69" @default.
• W1994043834 startingPage "E61" @default.
• W1994043834 abstract "In the present study, 2 alternative strategies to optimize ketorolac transdermal delivery, namely, prodrugs (polyoxyethylene glycol ester derivatives, I–IV) and nanostructured lipid carriers (NLC) were investigated. The synthesized prodrugs were chemically stable and easily degraded to the parent drug in human plasma. Ketorolac-loaded NLC with high drug content could be successfully prepared. The obtained products formulated into gels showed a different trend of drug permeation through human stratum corneum and epidermis. Particularly, skin permeation of ester prodrugs was significantly enhanced, apart from ester IV, compared with ketorolac, while the results of drug release from NLC outlined that these carriers were ineffective in increasing ketorolac percutaneous absorption owing to a higher degree of mutual interaction between the drug and carrier lipid matrix. Polyoxyethylene glycol esterification confirmed to be a suitable approach to enhance ketorolac transdermal delivery, while NLC seemed more appropriate for sustained release owing to the possible formation of a drug reservoir into the skin." @default.
• W1994043834 created "2016-06-24" @default.
• W1994043834 creator A5019677629 @default.
• W1994043834 creator A5033828754 @default.
• W1994043834 creator A5034661424 @default.
• W1994043834 creator A5055282178 @default.
• W1994043834 creator A5057763556 @default.
• W1994043834 creator A5066659467 @default.
• W1994043834 creator A5081664680 @default.
• W1994043834 date "2006-09-01" @default.
• W1994043834 modified "2023-10-06" @default.
• W1994043834 title "Evaluation of alternative strategies to optimize ketorolac transdermal delivery" @default.
• W1994043834 cites W141715706 @default.
• W1994043834 cites W1579046626 @default.
• W1994043834 cites W1963831149 @default.
• W1994043834 cites W1972733540 @default.
• W1994043834 cites W1976336238 @default.
• W1994043834 cites W1976761724 @default.
• W1994043834 cites W1978937436 @default.
• W1994043834 cites W1979512588 @default.
• W1994043834 cites W1981609978 @default.
• W1994043834 cites W1984038834 @default.
• W1994043834 cites W1986329432 @default.
• W1994043834 cites W1987843934 @default.
• W1994043834 cites W1988843459 @default.
• W1994043834 cites W1994381824 @default.
• W1994043834 cites W2004144092 @default.
• W1994043834 cites W2007995278 @default.
• W1994043834 cites W2012466429 @default.
• W1994043834 cites W2020218906 @default.
• W1994043834 cites W2020375551 @default.
• W1994043834 cites W2027674790 @default.
• W1994043834 cites W2035333527 @default.
• W1994043834 cites W2057283486 @default.
• W1994043834 cites W2058009653 @default.
• W1994043834 cites W2101453828 @default.
• W1994043834 cites W2103741853 @default.
• W1994043834 cites W2108639251 @default.
• W1994043834 cites W2112281258 @default.
• W1994043834 cites W2141331305 @default.
• W1994043834 cites W2144969116 @default.
• W1994043834 cites W2163793062 @default.
• W1994043834 cites W2321795952 @default.
• W1994043834 doi "https://doi.org/10.1208/pt070364" @default.
• W1994043834 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2750506" @default.
• W1994043834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17025245" @default.
• W1994043834 hasPublicationYear "2006" @default.
• W1994043834 type Work @default.
• W1994043834 sameAs 1994043834 @default.
• W1994043834 citedByCount "72" @default.
• W1994043834 countsByYear W19940438342012 @default.
• W1994043834 countsByYear W19940438342013 @default.
• W1994043834 countsByYear W19940438342014 @default.
• W1994043834 countsByYear W19940438342015 @default.
• W1994043834 countsByYear W19940438342016 @default.
• W1994043834 countsByYear W19940438342017 @default.
• W1994043834 countsByYear W19940438342018 @default.
• W1994043834 countsByYear W19940438342019 @default.
• W1994043834 countsByYear W19940438342020 @default.
• W1994043834 countsByYear W19940438342021 @default.
• W1994043834 countsByYear W19940438342022 @default.
• W1994043834 crossrefType "journal-article" @default.
• W1994043834 hasAuthorship W1994043834A5019677629 @default.
• W1994043834 hasAuthorship W1994043834A5033828754 @default.
• W1994043834 hasAuthorship W1994043834A5034661424 @default.
• W1994043834 hasAuthorship W1994043834A5055282178 @default.
• W1994043834 hasAuthorship W1994043834A5057763556 @default.
• W1994043834 hasAuthorship W1994043834A5066659467 @default.
• W1994043834 hasAuthorship W1994043834A5081664680 @default.
• W1994043834 hasBestOaLocation W19940438342 @default.
• W1994043834 hasConcept C108215921 @default.
• W1994043834 hasConcept C142724271 @default.
• W1994043834 hasConcept C178790620 @default.
• W1994043834 hasConcept C185592680 @default.
• W1994043834 hasConcept C205679159 @default.
• W1994043834 hasConcept C2778370115 @default.
• W1994043834 hasConcept C2778446825 @default.
• W1994043834 hasConcept C2779820397 @default.
• W1994043834 hasConcept C2780035454 @default.
• W1994043834 hasConcept C2780820201 @default.
• W1994043834 hasConcept C41625074 @default.
• W1994043834 hasConcept C43617362 @default.
• W1994043834 hasConcept C50670333 @default.
• W1994043834 hasConcept C55493867 @default.
• W1994043834 hasConcept C71924100 @default.
• W1994043834 hasConcept C98274493 @default.
• W1994043834 hasConceptScore W1994043834C108215921 @default.
• W1994043834 hasConceptScore W1994043834C142724271 @default.
• W1994043834 hasConceptScore W1994043834C178790620 @default.
• W1994043834 hasConceptScore W1994043834C185592680 @default.
• W1994043834 hasConceptScore W1994043834C205679159 @default.
• W1994043834 hasConceptScore W1994043834C2778370115 @default.
• W1994043834 hasConceptScore W1994043834C2778446825 @default.
• W1994043834 hasConceptScore W1994043834C2779820397 @default.
• W1994043834 hasConceptScore W1994043834C2780035454 @default.
• W1994043834 hasConceptScore W1994043834C2780820201 @default.
• W1994043834 hasConceptScore W1994043834C41625074 @default.
• W1994043834 hasConceptScore W1994043834C43617362 @default.

• next