Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994044186> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W1994044186 endingPage "2614" @default.
- W1994044186 startingPage "2610" @default.
- W1994044186 abstract "In order to redefine the effectiveness of 5-fluorouracil (5-FU) as palliative therapy in patients with metastatic colorectal carcinoma, and to compare the effectiveness of 6-thioguanine (6-TG) with that of 5-FU, we studied 176 patients with metastatic colorectal carcinoma in a randomized prospective trial (SEG 79GI268). The pretreatment performance status of all patients was greater than 50% (ambulatory), and there was an equal distribution of patients with favorable pretreatment characteristics into each of the treatment regimens. Complete responses were only seen to 5-FU, but were obtained in only 3% of instances. The overall complete plus partial response rates were not different for 5-FU (8%) versus 6-TG (3%), or for patients who had shown prior progression on chemotherapy and who then received 6-TG in a nonrandomized fashion (7%). The time to tumor progression on each of the treatment programs was similar, 1.0 months. Survival was also similar in each regimen in the randomized study (6.3 months for 5-FU versus 7.9 months for 6-TG). However, survival was only 4.8 months for patients with previously drug-resistant tumors treated with 6-TG in the nonrandomized arm. in 16 patients failing 6-TG who then received 5-FU, there were no objective responses. Similarly, in patients failing 5-FU on this study who then received 6-TG, there were no responses in nine patients. Dose-limiting toxicity was observed in 40% to 51% of patients, and consisted of myelosuppression, vomiting, or diarrhea. It is concluded that 5-FU is a minimally effective agent in a very small number of patients with metastatic colorectal carcinoma. The drug 6-TG is equally ineffective in this setting. Alternative treatment programs to the systemic use of 5-FU should be considered in patients requiring palliative chemotherapy." @default.
- W1994044186 created "2016-06-24" @default.
- W1994044186 creator A5074927931 @default.
- W1994044186 creator A5075115722 @default.
- W1994044186 creator A5078882215 @default.
- W1994044186 creator A5085978683 @default.
- W1994044186 date "1984-06-15" @default.
- W1994044186 modified "2023-10-17" @default.
- W1994044186 title "Prospective randomized reappraisal of 5-fluorouracil in metastatic colorectal carcinoma a comparative trial with 6-thioguanine" @default.
- W1994044186 cites W2015052490 @default.
- W1994044186 cites W2224109029 @default.
- W1994044186 doi "https://doi.org/10.1002/1097-0142(19840615)53:12<2610::aid-cncr2820531207>3.0.co;2-9" @default.
- W1994044186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6372981" @default.
- W1994044186 hasPublicationYear "1984" @default.
- W1994044186 type Work @default.
- W1994044186 sameAs 1994044186 @default.
- W1994044186 citedByCount "26" @default.
- W1994044186 countsByYear W19940441862014 @default.
- W1994044186 countsByYear W19940441862019 @default.
- W1994044186 countsByYear W19940441862020 @default.
- W1994044186 countsByYear W19940441862023 @default.
- W1994044186 crossrefType "journal-article" @default.
- W1994044186 hasAuthorship W1994044186A5074927931 @default.
- W1994044186 hasAuthorship W1994044186A5075115722 @default.
- W1994044186 hasAuthorship W1994044186A5078882215 @default.
- W1994044186 hasAuthorship W1994044186A5085978683 @default.
- W1994044186 hasBestOaLocation W19940441861 @default.
- W1994044186 hasConcept C121608353 @default.
- W1994044186 hasConcept C126322002 @default.
- W1994044186 hasConcept C141071460 @default.
- W1994044186 hasConcept C143998085 @default.
- W1994044186 hasConcept C168563851 @default.
- W1994044186 hasConcept C188816634 @default.
- W1994044186 hasConcept C2776694085 @default.
- W1994044186 hasConcept C2777546739 @default.
- W1994044186 hasConcept C2780456651 @default.
- W1994044186 hasConcept C2780852908 @default.
- W1994044186 hasConcept C2781413609 @default.
- W1994044186 hasConcept C29730261 @default.
- W1994044186 hasConcept C35785553 @default.
- W1994044186 hasConcept C526805850 @default.
- W1994044186 hasConcept C71924100 @default.
- W1994044186 hasConcept C90924648 @default.
- W1994044186 hasConceptScore W1994044186C121608353 @default.
- W1994044186 hasConceptScore W1994044186C126322002 @default.
- W1994044186 hasConceptScore W1994044186C141071460 @default.
- W1994044186 hasConceptScore W1994044186C143998085 @default.
- W1994044186 hasConceptScore W1994044186C168563851 @default.
- W1994044186 hasConceptScore W1994044186C188816634 @default.
- W1994044186 hasConceptScore W1994044186C2776694085 @default.
- W1994044186 hasConceptScore W1994044186C2777546739 @default.
- W1994044186 hasConceptScore W1994044186C2780456651 @default.
- W1994044186 hasConceptScore W1994044186C2780852908 @default.
- W1994044186 hasConceptScore W1994044186C2781413609 @default.
- W1994044186 hasConceptScore W1994044186C29730261 @default.
- W1994044186 hasConceptScore W1994044186C35785553 @default.
- W1994044186 hasConceptScore W1994044186C526805850 @default.
- W1994044186 hasConceptScore W1994044186C71924100 @default.
- W1994044186 hasConceptScore W1994044186C90924648 @default.
- W1994044186 hasIssue "12" @default.
- W1994044186 hasLocation W19940441861 @default.
- W1994044186 hasLocation W19940441862 @default.
- W1994044186 hasOpenAccess W1994044186 @default.
- W1994044186 hasPrimaryLocation W19940441861 @default.
- W1994044186 hasRelatedWork W1969245478 @default.
- W1994044186 hasRelatedWork W1976994629 @default.
- W1994044186 hasRelatedWork W1979130534 @default.
- W1994044186 hasRelatedWork W2047376960 @default.
- W1994044186 hasRelatedWork W2066883220 @default.
- W1994044186 hasRelatedWork W2361446859 @default.
- W1994044186 hasRelatedWork W2368410016 @default.
- W1994044186 hasRelatedWork W2370068476 @default.
- W1994044186 hasRelatedWork W2377187185 @default.
- W1994044186 hasRelatedWork W2388348438 @default.
- W1994044186 hasVolume "53" @default.
- W1994044186 isParatext "false" @default.
- W1994044186 isRetracted "false" @default.
- W1994044186 magId "1994044186" @default.
- W1994044186 workType "article" @default.