FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994048537> ?p ?o ?g. }

• W1994048537 endingPage "e53189" @default.
• W1994048537 startingPage "e53189" @default.
• W1994048537 abstract "Background Pituitary stalk interruption syndrome (PSIS) may induce an isolated growth hormone (GH) deficiency or multiple hypothalamic-pituitary (HP) deficiencies. Patients with multiple HP deficiencies, primarily those with adrenocorticotropin (ACTH) deficiency, are at increased risk of morbidity and mortality. Our objective was to identify the factors influencing each symptom and the MRI features of the syndrome to enhance its diagnosis and genetic analysis. Methods This study was a retrospective, single-center, case-cohort study of 53 patients with PSIS who had reached pubertal age. Results Patients were classified as having an isolated GH deficiency (n = 24, Group 1) or HP deficiencies (n = 29, Group 2); of these, 19 had complete HP deficiency, and 10 had GH deficiency associated with TSH (n = 4), TSH and ACTH (n = 3), TSH and gonadotropin (n = 1) deficiencies or amenorrhea (n = 2). The following features were less frequent in Group 1 than in Group 2: breech presentation (4% vs 35%, P = 0.008), hypoglycemia (0% vs 59%, P<0.00001), micropenis (13% vs 69%, P<0.003), hypothalamic origin (0% vs 52%, P<0.000001), ophthalmic malformation (8% vs 38%, P<0.02) and psychomotor delay (0% vs 31%, P<0.004). The frequencies of all other malformations were similar in both groups (37% vs 59%). A visible pituitary stalk was characteristic of patients belonging to Group 1 (P<0.0002). The GH peak was greater in Group 1 than in Group 2 (P<0.0003), as was the anterior pituitary height (P = 0.01). Conclusion The factors that best discriminate patients with multiple HP deficiencies from those with an isolated GH deficiency are breech presentation, hypoglycemia, and micropenis. No patient with an isolated GH deficiency had psychomotor delay, but associated malformations and/or syndromes, with the exception of ophthalmic disorders, occurred with similar frequencies in both groups. We have also shown that each of the above characteristics is associated with a given HP deficiency and/or malformation/syndrome in the majority of cases." @default.
• W1994048537 created "2016-06-24" @default.
• W1994048537 creator A5040699219 @default.
• W1994048537 creator A5040917457 @default.
• W1994048537 creator A5063726428 @default.
• W1994048537 creator A5079392368 @default.
• W1994048537 creator A5081877056 @default.
• W1994048537 date "2013-01-07" @default.
• W1994048537 modified "2023-10-18" @default.
• W1994048537 title "Pituitary Stalk Interruption Syndrome in 53 Postpubertal Patients: Factors Influencing the Heterogeneity of Its Presentation" @default.
• W1994048537 cites W1950375808 @default.
• W1994048537 cites W1979219368 @default.
• W1994048537 cites W1980044926 @default.
• W1994048537 cites W1983485440 @default.
• W1994048537 cites W1990462391 @default.
• W1994048537 cites W1995442506 @default.
• W1994048537 cites W1996331614 @default.
• W1994048537 cites W2000148711 @default.
• W1994048537 cites W2003051889 @default.
• W1994048537 cites W2016304478 @default.
• W1994048537 cites W2020815646 @default.
• W1994048537 cites W2030788402 @default.
• W1994048537 cites W2045970938 @default.
• W1994048537 cites W2070580286 @default.
• W1994048537 cites W2089651359 @default.
• W1994048537 cites W2090067436 @default.
• W1994048537 cites W2110207339 @default.
• W1994048537 cites W2126485425 @default.
• W1994048537 cites W2129574146 @default.
• W1994048537 cites W2147620351 @default.
• W1994048537 cites W2154083248 @default.
• W1994048537 cites W2156792518 @default.
• W1994048537 cites W2166074019 @default.
• W1994048537 doi "https://doi.org/10.1371/journal.pone.0053189" @default.
• W1994048537 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3538767" @default.
• W1994048537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23308160" @default.
• W1994048537 hasPublicationYear "2013" @default.
• W1994048537 type Work @default.
• W1994048537 sameAs 1994048537 @default.
• W1994048537 citedByCount "24" @default.
• W1994048537 countsByYear W19940485372013 @default.
• W1994048537 countsByYear W19940485372014 @default.
• W1994048537 countsByYear W19940485372015 @default.
• W1994048537 countsByYear W19940485372016 @default.
• W1994048537 countsByYear W19940485372017 @default.
• W1994048537 countsByYear W19940485372018 @default.
• W1994048537 countsByYear W19940485372019 @default.
• W1994048537 countsByYear W19940485372020 @default.
• W1994048537 countsByYear W19940485372021 @default.
• W1994048537 countsByYear W19940485372022 @default.
• W1994048537 countsByYear W19940485372023 @default.
• W1994048537 crossrefType "journal-article" @default.
• W1994048537 hasAuthorship W1994048537A5040699219 @default.
• W1994048537 hasAuthorship W1994048537A5040917457 @default.
• W1994048537 hasAuthorship W1994048537A5063726428 @default.
• W1994048537 hasAuthorship W1994048537A5079392368 @default.
• W1994048537 hasAuthorship W1994048537A5081877056 @default.
• W1994048537 hasBestOaLocation W19940485371 @default.
• W1994048537 hasConcept C126322002 @default.
• W1994048537 hasConcept C134018914 @default.
• W1994048537 hasConcept C141071460 @default.
• W1994048537 hasConcept C167135981 @default.
• W1994048537 hasConcept C187212893 @default.
• W1994048537 hasConcept C2777261759 @default.
• W1994048537 hasConcept C2777658017 @default.
• W1994048537 hasConcept C2777990738 @default.
• W1994048537 hasConcept C2778491484 @default.
• W1994048537 hasConcept C2779029589 @default.
• W1994048537 hasConcept C2779306644 @default.
• W1994048537 hasConcept C2779610619 @default.
• W1994048537 hasConcept C2779952775 @default.
• W1994048537 hasConcept C2780668416 @default.
• W1994048537 hasConcept C2984496839 @default.
• W1994048537 hasConcept C71315377 @default.
• W1994048537 hasConcept C71924100 @default.
• W1994048537 hasConcept C90924648 @default.
• W1994048537 hasConceptScore W1994048537C126322002 @default.
• W1994048537 hasConceptScore W1994048537C134018914 @default.
• W1994048537 hasConceptScore W1994048537C141071460 @default.
• W1994048537 hasConceptScore W1994048537C167135981 @default.
• W1994048537 hasConceptScore W1994048537C187212893 @default.
• W1994048537 hasConceptScore W1994048537C2777261759 @default.
• W1994048537 hasConceptScore W1994048537C2777658017 @default.
• W1994048537 hasConceptScore W1994048537C2777990738 @default.
• W1994048537 hasConceptScore W1994048537C2778491484 @default.
• W1994048537 hasConceptScore W1994048537C2779029589 @default.
• W1994048537 hasConceptScore W1994048537C2779306644 @default.
• W1994048537 hasConceptScore W1994048537C2779610619 @default.
• W1994048537 hasConceptScore W1994048537C2779952775 @default.
• W1994048537 hasConceptScore W1994048537C2780668416 @default.
• W1994048537 hasConceptScore W1994048537C2984496839 @default.
• W1994048537 hasConceptScore W1994048537C71315377 @default.
• W1994048537 hasConceptScore W1994048537C71924100 @default.
• W1994048537 hasConceptScore W1994048537C90924648 @default.
• W1994048537 hasIssue "1" @default.
• W1994048537 hasLocation W19940485371 @default.
• W1994048537 hasLocation W19940485372 @default.
• W1994048537 hasLocation W19940485373 @default.

• next