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• W1994059028 abstract "Although the overall incidence of primary malignant brain tumours, 6.6 per 100,000 [1] Polednak A.P. Flannery J.T. Brain, other central nervous system, and eye cancer. Cancer 75. 1995; : 330-337 Crossref PubMed Scopus (98) Google Scholar is relatively low compared to other tumours, with a median survival time of less than 2 years, they are nonetheless among the most lethal forms of cancer. 2 Greenlee R.T. Hill-Harmon M.B. Murray T. Thun M. Cancer statistics, 2001. CA Cancer J Clin. 2001; 51: 15-36 Crossref PubMed Scopus (3315) Google Scholar , 3 Mahaley Jr., M.S. Mettlin C. Natarajan N. Laws Jr., E.R. Peace B.B. Analysis of patterns of care of brain tumor patients in the United States: a study of the Brain Tumor Section of the AANS and the CNS and the Commission on Cancer of the ACS. Clin Neurosurg. 1990; 36: 347-352 PubMed Google Scholar Additionally, the fact that little is known about the etiology of malignant brain tumours as well as the paucity of identifiable risk factors in the disease makes their prevention and treatment especially challenging. Understanding the basic biology and tumorigenesis involved in the formation of malignant brain tumors is thus of paramount importance in developing new therapeutic options in their treatment." @default.
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• W1994059028 date "2005-01-01" @default.
• W1994059028 modified "2023-10-05" @default.
• W1994059028 title "Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge" @default.
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• W1994059028 doi "https://doi.org/10.1016/j.jocn.2004.04.001" @default.
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