Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994076516> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W1994076516 endingPage "336" @default.
- W1994076516 startingPage "323" @default.
- W1994076516 abstract "Since the mammalian renal cortex avidly metabolizes prostaglandin E2 (PGE2), we examined the importance of renal metabolism of PGE2 in determining its renal vascular activity in the dog. We used 13, 14 dihydro PGE2 (DHPGE2) as a model compound to study this because DHPGE2 retains similar activity to the parent prostaglandin, PGE2, but is a poorer substrate than PGE2 for both the metabolism and the cellular uptake of the prostaglandins. Using dog renal cortical slices, we found that under similar experimental conditions, PGE2 was metabolized several-fold faster than DHPGE2. Both prostaglandins were metabolized to the 15 keto 13, 14 dihydro PGE2, which was positively identified using GC-MS. In vivo, we infused increasing concentrations of DHPGE2 into the renal artery of dogs and measured renal hemodynamic changes using radioactive microspheres. DHPGE2 was a potent renal vasodilator beginning at an infusion rate of 10−9g/kg/min. When compared to PGE2, DHPGE2 was about 10 times more potent in affecting renal vasodilation. The intrarenal redistribution of blood flow towards the inner cortex seen with DHPGE2 was identical to that seen with PGE2. We conclude that renal catabolism of PGE2 is very important in limiting the in vivo biological activity of PGE2, but regional differences in metabolism of PGE2 within the cortex are an unlikely determinant of the pattern of redistribution of renal blood flow." @default.
- W1994076516 created "2016-06-24" @default.
- W1994076516 creator A5001982475 @default.
- W1994076516 creator A5056820048 @default.
- W1994076516 creator A5077616203 @default.
- W1994076516 date "1979-03-01" @default.
- W1994076516 modified "2023-10-15" @default.
- W1994076516 title "The role of renal metabolism of PGE2 in determining its activity as a renal vasodilator in the dog" @default.
- W1994076516 cites W1555140230 @default.
- W1994076516 cites W1604119828 @default.
- W1994076516 cites W1993506643 @default.
- W1994076516 cites W1994010359 @default.
- W1994076516 cites W1999086285 @default.
- W1994076516 cites W2014834561 @default.
- W1994076516 cites W2026425270 @default.
- W1994076516 cites W2028834187 @default.
- W1994076516 cites W2030036305 @default.
- W1994076516 cites W2123686575 @default.
- W1994076516 cites W2132924014 @default.
- W1994076516 cites W2151191105 @default.
- W1994076516 cites W2164260555 @default.
- W1994076516 doi "https://doi.org/10.1016/s0090-6980(79)80001-5" @default.
- W1994076516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/472331" @default.
- W1994076516 hasPublicationYear "1979" @default.
- W1994076516 type Work @default.
- W1994076516 sameAs 1994076516 @default.
- W1994076516 citedByCount "9" @default.
- W1994076516 crossrefType "journal-article" @default.
- W1994076516 hasAuthorship W1994076516A5001982475 @default.
- W1994076516 hasAuthorship W1994076516A5056820048 @default.
- W1994076516 hasAuthorship W1994076516A5077616203 @default.
- W1994076516 hasConcept C120770815 @default.
- W1994076516 hasConcept C126322002 @default.
- W1994076516 hasConcept C134018914 @default.
- W1994076516 hasConcept C142225936 @default.
- W1994076516 hasConcept C150903083 @default.
- W1994076516 hasConcept C169760540 @default.
- W1994076516 hasConcept C185592680 @default.
- W1994076516 hasConcept C207001950 @default.
- W1994076516 hasConcept C2776634560 @default.
- W1994076516 hasConcept C2777348757 @default.
- W1994076516 hasConcept C2777956040 @default.
- W1994076516 hasConcept C2778577996 @default.
- W1994076516 hasConcept C2780091579 @default.
- W1994076516 hasConcept C2780664492 @default.
- W1994076516 hasConcept C62231903 @default.
- W1994076516 hasConcept C71924100 @default.
- W1994076516 hasConcept C86803240 @default.
- W1994076516 hasConcept C96942376 @default.
- W1994076516 hasConceptScore W1994076516C120770815 @default.
- W1994076516 hasConceptScore W1994076516C126322002 @default.
- W1994076516 hasConceptScore W1994076516C134018914 @default.
- W1994076516 hasConceptScore W1994076516C142225936 @default.
- W1994076516 hasConceptScore W1994076516C150903083 @default.
- W1994076516 hasConceptScore W1994076516C169760540 @default.
- W1994076516 hasConceptScore W1994076516C185592680 @default.
- W1994076516 hasConceptScore W1994076516C207001950 @default.
- W1994076516 hasConceptScore W1994076516C2776634560 @default.
- W1994076516 hasConceptScore W1994076516C2777348757 @default.
- W1994076516 hasConceptScore W1994076516C2777956040 @default.
- W1994076516 hasConceptScore W1994076516C2778577996 @default.
- W1994076516 hasConceptScore W1994076516C2780091579 @default.
- W1994076516 hasConceptScore W1994076516C2780664492 @default.
- W1994076516 hasConceptScore W1994076516C62231903 @default.
- W1994076516 hasConceptScore W1994076516C71924100 @default.
- W1994076516 hasConceptScore W1994076516C86803240 @default.
- W1994076516 hasConceptScore W1994076516C96942376 @default.
- W1994076516 hasIssue "3" @default.
- W1994076516 hasLocation W19940765161 @default.
- W1994076516 hasLocation W19940765162 @default.
- W1994076516 hasOpenAccess W1994076516 @default.
- W1994076516 hasPrimaryLocation W19940765161 @default.
- W1994076516 hasRelatedWork W1965773364 @default.
- W1994076516 hasRelatedWork W2011991595 @default.
- W1994076516 hasRelatedWork W2062430615 @default.
- W1994076516 hasRelatedWork W2075937877 @default.
- W1994076516 hasRelatedWork W2231257984 @default.
- W1994076516 hasRelatedWork W2349611002 @default.
- W1994076516 hasRelatedWork W2401507791 @default.
- W1994076516 hasRelatedWork W2418823386 @default.
- W1994076516 hasRelatedWork W2443834361 @default.
- W1994076516 hasRelatedWork W80508350 @default.
- W1994076516 hasVolume "17" @default.
- W1994076516 isParatext "false" @default.
- W1994076516 isRetracted "false" @default.
- W1994076516 magId "1994076516" @default.
- W1994076516 workType "article" @default.