FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994082007> ?p ?o ?g. }

• W1994082007 endingPage "350" @default.
• W1994082007 startingPage "340" @default.
• W1994082007 abstract "Although matrix metalloproteinases (MMPs) were initially thought to result primarily in extracellular matrix degradation, certain MMP types, such as membrane type-1 (MT1) MMP, may also be involved in profibrotic cascades through hydrolysis of latency-associated transforming growth factor-binding protein (LTBP-1) and activation of transforming growth factor-dependent profibrotic signaling. The present study tested the hypothesis that MT1-MMP plays a direct role in the matrix remodeling response to a left ventricular (LV) pressure overload (PO) stimulus.Wild-type (WT) and transgenic mice with cardiac-restricted MT1-MMP overexpression or MT1-MMP reduced expression underwent PO for 4 weeks. PO resulted in a 57% increase in LV mass (no change in LV end diastolic volume, resulting in an increase in the LV mass/volume ratio consistent with concentric remodeling), a 60% increase in MT1-MMP-mediated LTBP-1 hydrolysis and a 190% increase in collagen content in WT mice. Although LV mass was similar among WT, MT1-MMP overexpression, and MT1-MMP reduced expression after PO, significant differences in LV function, MT1-MMP-mediated LTBP-1 hydrolysis, and collagen content occurred. PO in MT1-MMP overexpression increased LTBP-1 hydrolysis (18%), collagen content (60%), and left atrial dimension (19%; indicative of LV diastolic dysfunction) when compared with WT. PO in MT1-MMP reduced expression reduced left atrial dimension (19%), LTBP-1 hydrolysis (40%), and collagen content (32%) when compared with both WT.Despite an equivalent PO stimulus and magnitude of LV myocardial growth, altering MT1-MMP levels caused specific matrix-dependent changes in remodeling, thereby demonstrating a mechanistic role in the development of the maladaptive remodeling and myocardial fibrotic response to PO." @default.
• W1994082007 created "2016-06-24" @default.
• W1994082007 creator A5014049392 @default.
• W1994082007 creator A5029674413 @default.
• W1994082007 creator A5030359399 @default.
• W1994082007 creator A5041498326 @default.
• W1994082007 creator A5042887348 @default.
• W1994082007 creator A5047833899 @default.
• W1994082007 creator A5053390482 @default.
• W1994082007 creator A5083914588 @default.
• W1994082007 date "2014-03-01" @default.
• W1994082007 modified "2023-10-06" @default.
• W1994082007 title "Mechanistic Relationship Between Membrane Type-1 Matrix Metalloproteinase and the Myocardial Response to Pressure Overload" @default.
• W1994082007 cites W1502782135 @default.
• W1994082007 cites W1505060751 @default.
• W1994082007 cites W1968084778 @default.
• W1994082007 cites W1968181166 @default.
• W1994082007 cites W1968521818 @default.
• W1994082007 cites W1979190868 @default.
• W1994082007 cites W1986011418 @default.
• W1994082007 cites W1988284222 @default.
• W1994082007 cites W2004656949 @default.
• W1994082007 cites W2029513470 @default.
• W1994082007 cites W2031495896 @default.
• W1994082007 cites W2032211678 @default.
• W1994082007 cites W2033736618 @default.
• W1994082007 cites W2040759573 @default.
• W1994082007 cites W2043068076 @default.
• W1994082007 cites W2057490727 @default.
• W1994082007 cites W2059104750 @default.
• W1994082007 cites W2066665398 @default.
• W1994082007 cites W2072011504 @default.
• W1994082007 cites W2072085629 @default.
• W1994082007 cites W2072626568 @default.
• W1994082007 cites W2074156641 @default.
• W1994082007 cites W2076911162 @default.
• W1994082007 cites W2077271417 @default.
• W1994082007 cites W2079189474 @default.
• W1994082007 cites W2085786241 @default.
• W1994082007 cites W2086364694 @default.
• W1994082007 cites W2088776044 @default.
• W1994082007 cites W2101099004 @default.
• W1994082007 cites W2104676435 @default.
• W1994082007 cites W2109281287 @default.
• W1994082007 cites W2111836905 @default.
• W1994082007 cites W2113309273 @default.
• W1994082007 cites W2125639808 @default.
• W1994082007 cites W2128503400 @default.
• W1994082007 cites W2134088866 @default.
• W1994082007 cites W2135888652 @default.
• W1994082007 cites W2138173733 @default.
• W1994082007 cites W2145865564 @default.
• W1994082007 cites W2148075660 @default.
• W1994082007 cites W2149841172 @default.
• W1994082007 cites W2150888479 @default.
• W1994082007 cites W2153760303 @default.
• W1994082007 cites W2158987422 @default.
• W1994082007 cites W2161987480 @default.
• W1994082007 cites W2165159075 @default.
• W1994082007 cites W2166997892 @default.
• W1994082007 cites W2168621719 @default.
• W1994082007 cites W2171820373 @default.
• W1994082007 cites W2622773808 @default.
• W1994082007 cites W27593660 @default.
• W1994082007 doi "https://doi.org/10.1161/circheartfailure.113.000984" @default.
• W1994082007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3961496" @default.
• W1994082007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24395927" @default.
• W1994082007 hasPublicationYear "2014" @default.
• W1994082007 type Work @default.
• W1994082007 sameAs 1994082007 @default.
• W1994082007 citedByCount "17" @default.
• W1994082007 countsByYear W19940820072014 @default.
• W1994082007 countsByYear W19940820072015 @default.
• W1994082007 countsByYear W19940820072016 @default.
• W1994082007 countsByYear W19940820072018 @default.
• W1994082007 countsByYear W19940820072019 @default.
• W1994082007 countsByYear W19940820072021 @default.
• W1994082007 countsByYear W19940820072022 @default.
• W1994082007 crossrefType "journal-article" @default.
• W1994082007 hasAuthorship W1994082007A5014049392 @default.
• W1994082007 hasAuthorship W1994082007A5029674413 @default.
• W1994082007 hasAuthorship W1994082007A5030359399 @default.
• W1994082007 hasAuthorship W1994082007A5041498326 @default.
• W1994082007 hasAuthorship W1994082007A5042887348 @default.
• W1994082007 hasAuthorship W1994082007A5047833899 @default.
• W1994082007 hasAuthorship W1994082007A5053390482 @default.
• W1994082007 hasAuthorship W1994082007A5083914588 @default.
• W1994082007 hasBestOaLocation W19940820071 @default.
• W1994082007 hasConcept C109523444 @default.
• W1994082007 hasConcept C118131993 @default.
• W1994082007 hasConcept C126322002 @default.
• W1994082007 hasConcept C134018914 @default.
• W1994082007 hasConcept C167414201 @default.
• W1994082007 hasConcept C185592680 @default.
• W1994082007 hasConcept C189165786 @default.
• W1994082007 hasConcept C2778271984 @default.
• W1994082007 hasConcept C3018791406 @default.
• W1994082007 hasConcept C55493867 @default.

• next