Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994082223> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1994082223 abstract "Two pituitaries from 7-week old female rats (Sprague-Dawley strain) were grafted under the capsule of the left kidney of 21-day old male rat. The pituitary grafted and sham-operated rats were hypophysectomized at 27 days of age. The hypophysectomized rats, in groups of 4, were given daily injections of 9 micrograms NIAMDD-oLH-23 (minimum effective dose) or saline for 3 days starting from day 29. Testicular homogenates were incubated with [3H]progesterone or [14C]4-androstene-3,17-dione, and enzyme activities per testes were estimated. Testicular HCG-binding sites were also measured. Hypophysectomy caused significant decreases in activities of testicular 5 alpha-reductase, 17-hydroxylase, and 17 beta-hydroxysteroid oxidoreductase. These decreased enzyme activities were significantly stimulated by LH treatment. Although pituitary grafts alone showed no effects on these enzyme activities in the testes of the hypophysectomized rats, the grafts significantly enhanced LH-stimulated 5 alpha-reductase activities but inhibited LH-stimulated 17-hydroxylase activity. Testicular LH/HCG receptors were significantly increased by the grafts, especially in the presence of LH, without affecting affinity for HCG. The present results demonstrate for the first time that hyperprolactinemia directly stimulates LH-stimulated 5 alpha-reductase activity in rat testes. The results also show that the same grafts directly inhibit LH-stimulated 17-hydroxylase activity, probably via postreceptor mechanisms." @default.
- W1994082223 created "2016-06-24" @default.
- W1994082223 creator A5003173325 @default.
- W1994082223 creator A5029317187 @default.
- W1994082223 creator A5032830362 @default.
- W1994082223 creator A5045586773 @default.
- W1994082223 creator A5069820981 @default.
- W1994082223 creator A5087013753 @default.
- W1994082223 creator A5090675780 @default.
- W1994082223 date "1986-06-01" @default.
- W1994082223 modified "2023-10-14" @default.
- W1994082223 title "Hyperprolactinemia enhances LH-stimulated 4-ENE-5α-reductase activity but inhibits LH-induced 17-hydroxylase activity in testes of hypophysectomized immature rats" @default.
- W1994082223 cites W1969849800 @default.
- W1994082223 cites W1975737524 @default.
- W1994082223 cites W1983481453 @default.
- W1994082223 cites W1983649348 @default.
- W1994082223 cites W1986899664 @default.
- W1994082223 cites W1988858003 @default.
- W1994082223 cites W1989173141 @default.
- W1994082223 cites W2000925905 @default.
- W1994082223 cites W2006418970 @default.
- W1994082223 cites W2009015955 @default.
- W1994082223 cites W2014566462 @default.
- W1994082223 cites W2014835074 @default.
- W1994082223 cites W2023091423 @default.
- W1994082223 cites W2027026615 @default.
- W1994082223 cites W2029781078 @default.
- W1994082223 cites W2032997885 @default.
- W1994082223 cites W2034386154 @default.
- W1994082223 cites W2034958855 @default.
- W1994082223 cites W2043133969 @default.
- W1994082223 cites W2061668109 @default.
- W1994082223 cites W2064881667 @default.
- W1994082223 cites W2067941649 @default.
- W1994082223 cites W2068058863 @default.
- W1994082223 cites W2069558628 @default.
- W1994082223 cites W2070659553 @default.
- W1994082223 cites W2083227795 @default.
- W1994082223 cites W2092196025 @default.
- W1994082223 cites W2108619254 @default.
- W1994082223 cites W2115469688 @default.
- W1994082223 cites W2136253949 @default.
- W1994082223 cites W2341173760 @default.
- W1994082223 cites W68215406 @default.
- W1994082223 doi "https://doi.org/10.1016/0022-4731(86)90383-3" @default.
- W1994082223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3016409" @default.
- W1994082223 hasPublicationYear "1986" @default.
- W1994082223 type Work @default.
- W1994082223 sameAs 1994082223 @default.
- W1994082223 citedByCount "2" @default.
- W1994082223 crossrefType "journal-article" @default.
- W1994082223 hasAuthorship W1994082223A5003173325 @default.
- W1994082223 hasAuthorship W1994082223A5029317187 @default.
- W1994082223 hasAuthorship W1994082223A5032830362 @default.
- W1994082223 hasAuthorship W1994082223A5045586773 @default.
- W1994082223 hasAuthorship W1994082223A5069820981 @default.
- W1994082223 hasAuthorship W1994082223A5087013753 @default.
- W1994082223 hasAuthorship W1994082223A5090675780 @default.
- W1994082223 hasConcept C126322002 @default.
- W1994082223 hasConcept C134018914 @default.
- W1994082223 hasConcept C181199279 @default.
- W1994082223 hasConcept C185592680 @default.
- W1994082223 hasConcept C2777397205 @default.
- W1994082223 hasConcept C2780104272 @default.
- W1994082223 hasConcept C28212737 @default.
- W1994082223 hasConcept C55493867 @default.
- W1994082223 hasConcept C71315377 @default.
- W1994082223 hasConcept C71924100 @default.
- W1994082223 hasConcept C86803240 @default.
- W1994082223 hasConceptScore W1994082223C126322002 @default.
- W1994082223 hasConceptScore W1994082223C134018914 @default.
- W1994082223 hasConceptScore W1994082223C181199279 @default.
- W1994082223 hasConceptScore W1994082223C185592680 @default.
- W1994082223 hasConceptScore W1994082223C2777397205 @default.
- W1994082223 hasConceptScore W1994082223C2780104272 @default.
- W1994082223 hasConceptScore W1994082223C28212737 @default.
- W1994082223 hasConceptScore W1994082223C55493867 @default.
- W1994082223 hasConceptScore W1994082223C71315377 @default.
- W1994082223 hasConceptScore W1994082223C71924100 @default.
- W1994082223 hasConceptScore W1994082223C86803240 @default.
- W1994082223 hasLocation W19940822231 @default.
- W1994082223 hasLocation W19940822232 @default.
- W1994082223 hasOpenAccess W1994082223 @default.
- W1994082223 hasPrimaryLocation W19940822231 @default.
- W1994082223 hasRelatedWork W1978650166 @default.
- W1994082223 hasRelatedWork W2015506195 @default.
- W1994082223 hasRelatedWork W2025395169 @default.
- W1994082223 hasRelatedWork W2027938488 @default.
- W1994082223 hasRelatedWork W2056503472 @default.
- W1994082223 hasRelatedWork W2059288635 @default.
- W1994082223 hasRelatedWork W2067359595 @default.
- W1994082223 hasRelatedWork W2075975156 @default.
- W1994082223 hasRelatedWork W2130367712 @default.
- W1994082223 hasRelatedWork W2232871498 @default.
- W1994082223 isParatext "false" @default.
- W1994082223 isRetracted "false" @default.
- W1994082223 magId "1994082223" @default.
- W1994082223 workType "article" @default.