FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994086339> ?p ?o ?g. }

• W1994086339 endingPage "5637" @default.
• W1994086339 startingPage "5634" @default.
• W1994086339 abstract "Quindolone derivatives, designed to target the malaria parasite digestive vacuole and heme detoxification pathway, have been synthesized by reaction with 2-chloro-N,N-diethylethanamine. This reaction gave N,O-, N,N- and O-alkylated products containing one or two basic side-chains. The compounds were evaluated for antiplasmodial activity against the chloroquine-resistant Plasmodium falciparum W2 strain and for cytotoxicity in HepG2 A16 hepatic cells. By incorporating alkylamine side chains and chlorine atoms in the quindolone nucleus we transformed the inactive tetracyclic parent quindolones into moderate or highly active and selective antimalarial compounds. The most active and selective compound, 5c, showed an IC(50)=51 nM for P. falciparum and a selectivity ratio of 98." @default.
• W1994086339 created "2016-06-24" @default.
• W1994086339 creator A5001320982 @default.
• W1994086339 creator A5009460259 @default.
• W1994086339 creator A5012165330 @default.
• W1994086339 creator A5015925791 @default.
• W1994086339 creator A5051777092 @default.
• W1994086339 creator A5052629340 @default.
• W1994086339 creator A5071697320 @default.
• W1994086339 creator A5077631479 @default.
• W1994086339 creator A5080951879 @default.
• W1994086339 creator A5085455504 @default.
• W1994086339 creator A5025292267 @default.
• W1994086339 date "2010-10-01" @default.
• W1994086339 modified "2023-09-26" @default.
• W1994086339 title "Bis-alkylamine quindolone derivatives as new antimalarial leads" @default.
• W1994086339 cites W1967649566 @default.
• W1994086339 cites W1989347774 @default.
• W1994086339 cites W1991597513 @default.
• W1994086339 cites W1998608454 @default.
• W1994086339 cites W1999644586 @default.
• W1994086339 cites W2001958266 @default.
• W1994086339 cites W2009146673 @default.
• W1994086339 cites W2011419101 @default.
• W1994086339 cites W2017878528 @default.
• W1994086339 cites W2018285919 @default.
• W1994086339 cites W2028302122 @default.
• W1994086339 cites W2037616231 @default.
• W1994086339 cites W2044565224 @default.
• W1994086339 cites W2045133086 @default.
• W1994086339 cites W2058070876 @default.
• W1994086339 cites W2076874871 @default.
• W1994086339 cites W2079908295 @default.
• W1994086339 cites W2089449548 @default.
• W1994086339 cites W2104114506 @default.
• W1994086339 cites W2118740862 @default.
• W1994086339 cites W2128157469 @default.
• W1994086339 cites W2146645376 @default.
• W1994086339 cites W2152613630 @default.
• W1994086339 cites W2168950392 @default.
• W1994086339 cites W2953052031 @default.
• W1994086339 cites W4233775358 @default.
• W1994086339 doi "https://doi.org/10.1016/j.bmcl.2010.08.043" @default.
• W1994086339 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20801652" @default.
• W1994086339 hasPublicationYear "2010" @default.
• W1994086339 type Work @default.
• W1994086339 sameAs 1994086339 @default.
• W1994086339 citedByCount "22" @default.
• W1994086339 countsByYear W19940863392012 @default.
• W1994086339 countsByYear W19940863392013 @default.
• W1994086339 countsByYear W19940863392014 @default.
• W1994086339 countsByYear W19940863392015 @default.
• W1994086339 countsByYear W19940863392016 @default.
• W1994086339 countsByYear W19940863392019 @default.
• W1994086339 countsByYear W19940863392021 @default.
• W1994086339 countsByYear W19940863392022 @default.
• W1994086339 countsByYear W19940863392023 @default.
• W1994086339 crossrefType "journal-article" @default.
• W1994086339 hasAuthorship W1994086339A5001320982 @default.
• W1994086339 hasAuthorship W1994086339A5009460259 @default.
• W1994086339 hasAuthorship W1994086339A5012165330 @default.
• W1994086339 hasAuthorship W1994086339A5015925791 @default.
• W1994086339 hasAuthorship W1994086339A5025292267 @default.
• W1994086339 hasAuthorship W1994086339A5051777092 @default.
• W1994086339 hasAuthorship W1994086339A5052629340 @default.
• W1994086339 hasAuthorship W1994086339A5071697320 @default.
• W1994086339 hasAuthorship W1994086339A5077631479 @default.
• W1994086339 hasAuthorship W1994086339A5080951879 @default.
• W1994086339 hasAuthorship W1994086339A5085455504 @default.
• W1994086339 hasConcept C109316439 @default.
• W1994086339 hasConcept C114373084 @default.
• W1994086339 hasConcept C118792377 @default.
• W1994086339 hasConcept C155647269 @default.
• W1994086339 hasConcept C161790260 @default.
• W1994086339 hasConcept C164361826 @default.
• W1994086339 hasConcept C178790620 @default.
• W1994086339 hasConcept C181199279 @default.
• W1994086339 hasConcept C185592680 @default.
• W1994086339 hasConcept C202751555 @default.
• W1994086339 hasConcept C203014093 @default.
• W1994086339 hasConcept C204921945 @default.
• W1994086339 hasConcept C21951064 @default.
• W1994086339 hasConcept C2776120307 @default.
• W1994086339 hasConcept C2776217839 @default.
• W1994086339 hasConcept C2777425658 @default.
• W1994086339 hasConcept C2778048844 @default.
• W1994086339 hasConcept C2778371730 @default.
• W1994086339 hasConcept C2908859342 @default.
• W1994086339 hasConcept C2993530813 @default.
• W1994086339 hasConcept C521977710 @default.
• W1994086339 hasConcept C55493867 @default.
• W1994086339 hasConcept C71240020 @default.
• W1994086339 hasConcept C86803240 @default.
• W1994086339 hasConceptScore W1994086339C109316439 @default.
• W1994086339 hasConceptScore W1994086339C114373084 @default.
• W1994086339 hasConceptScore W1994086339C118792377 @default.
• W1994086339 hasConceptScore W1994086339C155647269 @default.
• W1994086339 hasConceptScore W1994086339C161790260 @default.

• next