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• W1994088672 startingPage "961" @default.
• W1994088672 abstract "In 1796, Edward Jenner introduced the concept of vaccination with cowpox virus, an Orthopoxvirus within the family Poxviridae that elicits cross protective immunity against related orthopoxviruses, including smallpox virus (variola virus). Over time, vaccinia virus (VACV) replaced cowpox virus as the smallpox vaccine, and vaccination efforts eventually led to the successful global eradication of smallpox in 1979. VACV has many characteristics that make it an excellent vaccine and that were crucial for the successful eradication of smallpox, including (1) its exceptional thermal stability (a very important but uncommon characteristic in live vaccines), (2) its ability to elicit strong humoral and cell-mediated immune responses, (3) the fact that it is easy to propagate, and (4) that it is not oncogenic, given that VACV replication occurs exclusively within the host cell cytoplasm and there is no evidence that the viral genome integrates into the host genome. Since the eradication of smallpox, VACV has experienced a renaissance of interest as a viral vector for the development of recombinant vaccines, immunotherapies, and oncolytic therapies, as well as the development of next-generation smallpox vaccines. This revival is mainly due to the successful use and extensive characterization of VACV as a vaccine during the smallpox eradication campaign, along with the ability to genetically manipulate its large dsDNA genome while retaining infectivity and immunogenicity, its wide mammalian host range, and its natural tropism for tumor cells that allows its use as an oncolytic vector. This review provides an overview of new uses of VACV that are currently being explored for the development of vaccines, immunotherapeutics, and oncolytic virotherapies." @default.
• W1994088672 created "2016-06-24" @default.
• W1994088672 creator A5025021047 @default.
• W1994088672 creator A5025596847 @default.
• W1994088672 creator A5084193294 @default.
• W1994088672 date "2012-07-01" @default.
• W1994088672 modified "2023-10-11" @default.
• W1994088672 title "A vaccinia virus renaissance" @default.
• W1994088672 cites W1930702759 @default.
• W1994088672 cites W1966617868 @default.
• W1994088672 cites W1966819591 @default.
• W1994088672 cites W1971747284 @default.
• W1994088672 cites W1976215218 @default.
• W1994088672 cites W1978558644 @default.
• W1994088672 cites W1978767079 @default.
• W1994088672 cites W1979702687 @default.
• W1994088672 cites W1982338251 @default.
• W1994088672 cites W1982986428 @default.
• W1994088672 cites W1985991627 @default.
• W1994088672 cites W1994195272 @default.
• W1994088672 cites W1995166935 @default.
• W1994088672 cites W1997940634 @default.
• W1994088672 cites W1998836839 @default.
• W1994088672 cites W1999389341 @default.
• W1994088672 cites W1999944003 @default.
• W1994088672 cites W2004501737 @default.
• W1994088672 cites W2009198593 @default.
• W1994088672 cites W2010094323 @default.
• W1994088672 cites W2011291060 @default.
• W1994088672 cites W2011714586 @default.
• W1994088672 cites W2014694744 @default.
• W1994088672 cites W2014851436 @default.
• W1994088672 cites W2017353156 @default.
• W1994088672 cites W2020849247 @default.
• W1994088672 cites W2023833567 @default.
• W1994088672 cites W2024268171 @default.
• W1994088672 cites W2026108602 @default.
• W1994088672 cites W2027733213 @default.
• W1994088672 cites W2027765075 @default.
• W1994088672 cites W2030388818 @default.
• W1994088672 cites W2034226296 @default.
• W1994088672 cites W2039111762 @default.
• W1994088672 cites W2046130821 @default.
• W1994088672 cites W2046201973 @default.
• W1994088672 cites W2053893045 @default.
• W1994088672 cites W2054789512 @default.
• W1994088672 cites W2058988746 @default.
• W1994088672 cites W2062282746 @default.
• W1994088672 cites W2065461284 @default.
• W1994088672 cites W2069053672 @default.
• W1994088672 cites W2071193341 @default.
• W1994088672 cites W2072589605 @default.
• W1994088672 cites W2073162537 @default.
• W1994088672 cites W2074548951 @default.
• W1994088672 cites W2079647238 @default.
• W1994088672 cites W2083008217 @default.
• W1994088672 cites W2084903397 @default.
• W1994088672 cites W2088514475 @default.
• W1994088672 cites W2090208389 @default.
• W1994088672 cites W2092579135 @default.
• W1994088672 cites W2094697492 @default.
• W1994088672 cites W2095927984 @default.
• W1994088672 cites W2097771941 @default.
• W1994088672 cites W2099166974 @default.
• W1994088672 cites W2100342970 @default.
• W1994088672 cites W2101058247 @default.
• W1994088672 cites W2105595963 @default.
• W1994088672 cites W2107530112 @default.
• W1994088672 cites W2109081146 @default.
• W1994088672 cites W2114156781 @default.
• W1994088672 cites W2120262772 @default.
• W1994088672 cites W2131029141 @default.
• W1994088672 cites W2132287875 @default.
• W1994088672 cites W2132780249 @default.
• W1994088672 cites W2136599325 @default.
• W1994088672 cites W2147794515 @default.
• W1994088672 cites W2149024166 @default.
• W1994088672 cites W2151026229 @default.
• W1994088672 cites W2151381318 @default.
• W1994088672 cites W2152048324 @default.
• W1994088672 cites W2152422810 @default.
• W1994088672 cites W2155402817 @default.
• W1994088672 cites W2155846302 @default.
• W1994088672 cites W2156942868 @default.
• W1994088672 cites W2157215695 @default.
• W1994088672 cites W2158437004 @default.
• W1994088672 cites W2158769683 @default.
• W1994088672 cites W2160328215 @default.
• W1994088672 cites W2161473340 @default.
• W1994088672 cites W2165402419 @default.
• W1994088672 cites W2318382778 @default.
• W1994088672 doi "https://doi.org/10.4161/hv.21080" @default.
• W1994088672 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3495727" @default.
• W1994088672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22777090" @default.
• W1994088672 hasPublicationYear "2012" @default.
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