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- W1994093923 abstract "Lipin-1 is a protein that has dual functions as a phosphatidic acid phosphohydrolase (PAP) and a nuclear transcriptional coactivator. It remains unknown how the nuclear localization and coactivator functions of lipin-1 are regulated. Here, we show that lipin-1 (including both the alpha and beta isoforms) is modified by sumoylation at two consensus sumoylation sites. We are unable to detect sumoylation of the related proteins lipin-2 and lipin-3. Lipin-1 is sumoylated at relatively high levels in brain, where lipin-1α is the predominant form. In cultured embryonic cortical neurons and SH-SY5Y neuronal cells, ectopically expressed lipin-1α is localized in both the nucleus and the cytoplasm, and the nuclear localization is abrogated by mutating the consensus sumyolation motifs. The sumoylation site mutant of lipin-1α loses the capacity to coactivate the transcriptional (co-) activators PGC-1α and MEF2, consistent with its nuclear exclusion. Thus, these results show that sumoylation facilitates the nuclear localization and transcriptional coactivator behavior of lipin-1α that we observe in cultured neuronal cells, and suggest that lipin-1α may act as a sumoylation-regulated transcriptional coactivator in brain." @default.
- W1994093923 created "2016-06-24" @default.
- W1994093923 creator A5027353592 @default.
- W1994093923 creator A5063062861 @default.
- W1994093923 date "2009-09-15" @default.
- W1994093923 modified "2023-09-23" @default.
- W1994093923 title "Sumoylation Regulates Nuclear Localization of Lipin-1α in Neuronal Cells" @default.
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- W1994093923 doi "https://doi.org/10.1371/journal.pone.0007031" @default.
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