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• W1994100215 abstract "Understanding the role of fibroblasts in pathologic conditions is hampered by the absence of specific markers. Fibroblast-specific protein (FSP)1 has been suggested as a fibroblast-specific marker in normal and fibrotic tissues; FSP1 reporter mice and FSP1-Cre-driven gene deletion are considered reliable strategies to investigate fibroblast biology. Because fibroblasts are abundant in normal and injured mammalian hearts, we studied the identity of FSP1 + cells in the infarcted and remodeling myocardium using mice with green fluorescent protein (GFP) expression driven by the FSP1 promoter. Neonatal and adult mouse hearts had low numbers of FSP1 + cells. Myocardial infarction induced marked infiltration with FSP1-expressing cells that peaked after 72 h of reperfusion. Using flow cytometry, we identified 50% of FSP1 + cells as hematopoietic cells; many endothelial cells were also FSP1 + . Increased infiltration with FSP1 + cells was also noted in the pressure-overloaded myocardium. Although some FSP1 + cells had fibroblast morphology, >30% were identified as hematopoietic cells, endothelial cells, or vascular smooth muscle cells. In contrast, periostin did not stain leukocytes or vascular cells but labeled spindle-shaped interstitial cells and, as a typical matricellular protein, was deposited in the matrix. CD11b + myeloid cells sorted from the infarcted heart had higher FSP1 expression than corresponding CD11b-negative cells, highlighting the predominant expression by hematopoietic cells. FSP1 is not a specific marker for fibroblasts in cardiac remodeling and fibrosis." @default.
• W1994100215 created "2016-06-24" @default.
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• W1994100215 date "2013-11-01" @default.
• W1994100215 modified "2023-10-02" @default.
• W1994100215 title "Lack of specificity of fibroblast-specific protein 1 in cardiac remodeling and fibrosis" @default.
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• W1994100215 doi "https://doi.org/10.1152/ajpheart.00395.2013" @default.
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