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• W1994100903 abstract "Caspases, a family of cysteinyl aspartate-specific proteases plays a central role in the regulation and the execution of apoptotic cell death. Activation of caspases-3 stimulates a signaling pathway that ultimately leads to the death of the cell. Hence, caspase-3 has been proven to be an effective target for reducing the amount of cellular and tissue damage. In this work, comparative molecular similarity indices analysis (CoMSIA) was performed on a series of 3,4-dihydropyrimidoindolones derivatives which are inhibitors of caspase-3. The best predictions were obtained for CoMSIA model (<TEX>$q^2$</TEX> = 0.586, <TEX>$r^2$</TEX> = 0.955). The predictive ability of test set (<TEX>$r^2_{pred}$</TEX>) was 0.723. Statistical parameters from the generated QSAR models indicated the data is well fitted and have high predictive ability. Our theoretical results could be useful to design novel and more potent caspase-3 derivatives." @default.
• W1994100903 created "2016-06-24" @default.
• W1994100903 creator A5011856511 @default.
• W1994100903 creator A5087501075 @default.
• W1994100903 date "2014-12-31" @default.
• W1994100903 modified "2023-09-26" @default.
• W1994100903 title "Comparative Molecular Similarity Indices Analysis of Caspase-3 Inhibitors" @default.
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• W1994100903 doi "https://doi.org/10.13160/ricns.2014.7.4.227" @default.
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