Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994101211> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W1994101211 endingPage "141" @default.
- W1994101211 startingPage "135" @default.
- W1994101211 abstract "The hemodynamic and renal effects of atriopeptin II were investigated in rats, using electromagnetic flowmeters and thermodilution and clearance techniques, and its direct cardiac effects were studied in isolated rat atria and ventricular muscle strips. Atriopeptin II had no effect on the rate or force of contraction of rat cardiac tissue in vitro. In anesthetized rats, i.v. injections of 1, 3, 5, and 7 micrograms/kg induced only transient hemodynamic effects: blood pressure (BP) was briefly reduced, and renal blood flow (RBF) but not mesenteric blood flow (MBF) increased. Infusions over 30 min at rates of 0.3, 1, 3, and 10 micrograms/kg/min caused a fall in BP, mediated by a reduction of cardiac output (CO); RBF and MBF were decreased in a dose-related manner, and systemic and regional vascular resistances rose. A reduction of RBF was also observed in clearance experiments, but glomerular filtration rate remained unchanged and the filtration fraction increased significantly. Natriuresis occurred at all rates of atriopeptin tested (0.3, 1, and 3 micrograms/kg/min i.v.) These results suggest that i.v. injection of atriopeptin II induces transient hypotensive and regional vasodilatory effects. Upon i.v. infusion, BP is lowered by way of a reduction in CO, which is accompanied by systemic and regional vasoconstriction. The decrease in CO cannot be ascribed to a direct cardiodepressant action, and the effects on regional blood flows are probably due to reflex activation. The natriuretic effects of atriopeptin II are independent of renal vasodilatation and may be attributable to changes in intrarenal hemodynamics or to direct tubular effects." @default.
- W1994101211 created "2016-06-24" @default.
- W1994101211 creator A5005591249 @default.
- W1994101211 creator A5026149645 @default.
- W1994101211 creator A5054212860 @default.
- W1994101211 creator A5066810013 @default.
- W1994101211 creator A5090976492 @default.
- W1994101211 creator A5091154881 @default.
- W1994101211 date "1987-02-01" @default.
- W1994101211 modified "2023-09-26" @default.
- W1994101211 title "Systemic and Regional Hemodynamic Effects of Atriopeptin II in Anesthetized Rats" @default.
- W1994101211 doi "https://doi.org/10.1097/00005344-198702000-00002" @default.
- W1994101211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2435989" @default.
- W1994101211 hasPublicationYear "1987" @default.
- W1994101211 type Work @default.
- W1994101211 sameAs 1994101211 @default.
- W1994101211 citedByCount "12" @default.
- W1994101211 crossrefType "journal-article" @default.
- W1994101211 hasAuthorship W1994101211A5005591249 @default.
- W1994101211 hasAuthorship W1994101211A5026149645 @default.
- W1994101211 hasAuthorship W1994101211A5054212860 @default.
- W1994101211 hasAuthorship W1994101211A5066810013 @default.
- W1994101211 hasAuthorship W1994101211A5090976492 @default.
- W1994101211 hasAuthorship W1994101211A5091154881 @default.
- W1994101211 hasBestOaLocation W19941012111 @default.
- W1994101211 hasConcept C119584498 @default.
- W1994101211 hasConcept C120770815 @default.
- W1994101211 hasConcept C126322002 @default.
- W1994101211 hasConcept C134018914 @default.
- W1994101211 hasConcept C139940330 @default.
- W1994101211 hasConcept C142225936 @default.
- W1994101211 hasConcept C158846371 @default.
- W1994101211 hasConcept C174459258 @default.
- W1994101211 hasConcept C178853913 @default.
- W1994101211 hasConcept C185592680 @default.
- W1994101211 hasConcept C2779961880 @default.
- W1994101211 hasConcept C2781073237 @default.
- W1994101211 hasConcept C58245268 @default.
- W1994101211 hasConcept C71924100 @default.
- W1994101211 hasConcept C84393581 @default.
- W1994101211 hasConceptScore W1994101211C119584498 @default.
- W1994101211 hasConceptScore W1994101211C120770815 @default.
- W1994101211 hasConceptScore W1994101211C126322002 @default.
- W1994101211 hasConceptScore W1994101211C134018914 @default.
- W1994101211 hasConceptScore W1994101211C139940330 @default.
- W1994101211 hasConceptScore W1994101211C142225936 @default.
- W1994101211 hasConceptScore W1994101211C158846371 @default.
- W1994101211 hasConceptScore W1994101211C174459258 @default.
- W1994101211 hasConceptScore W1994101211C178853913 @default.
- W1994101211 hasConceptScore W1994101211C185592680 @default.
- W1994101211 hasConceptScore W1994101211C2779961880 @default.
- W1994101211 hasConceptScore W1994101211C2781073237 @default.
- W1994101211 hasConceptScore W1994101211C58245268 @default.
- W1994101211 hasConceptScore W1994101211C71924100 @default.
- W1994101211 hasConceptScore W1994101211C84393581 @default.
- W1994101211 hasIssue "2" @default.
- W1994101211 hasLocation W19941012111 @default.
- W1994101211 hasLocation W19941012112 @default.
- W1994101211 hasOpenAccess W1994101211 @default.
- W1994101211 hasPrimaryLocation W19941012111 @default.
- W1994101211 hasRelatedWork W1952674006 @default.
- W1994101211 hasRelatedWork W1979646332 @default.
- W1994101211 hasRelatedWork W1994101211 @default.
- W1994101211 hasRelatedWork W1996200052 @default.
- W1994101211 hasRelatedWork W2046947037 @default.
- W1994101211 hasRelatedWork W2052195065 @default.
- W1994101211 hasRelatedWork W2140497790 @default.
- W1994101211 hasRelatedWork W2145697629 @default.
- W1994101211 hasRelatedWork W2415587469 @default.
- W1994101211 hasRelatedWork W2467621631 @default.
- W1994101211 hasVolume "9" @default.
- W1994101211 isParatext "false" @default.
- W1994101211 isRetracted "false" @default.
- W1994101211 magId "1994101211" @default.
- W1994101211 workType "article" @default.