FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994102885> ?p ?o ?g. }

• W1994102885 endingPage "427" @default.
• W1994102885 startingPage "421" @default.
• W1994102885 abstract "Optimal antihypertensive therapy requires a multimodal approach based on lifestyle modification and, for most individuals, combination drug therapy. Recommendations from experts suggest that a combination of an agent that blocks the renin–angiotensin system (RAS), together with a vasodilator (generally a calcium-channel blocker or a thiazide-type diuretic), is most likely to control blood pressure and provide the widest overall cardiovascular protection. Understanding the opportunities afforded by the combination of RAS blockade with a calcium-channel blocker requires a discussion of basic and clinical science data. One new concept is that of ‘global’ or total RAS blockade. The impact of the RAS can be diminished or blocked by several different classes of drugs (central sympatholytics, β-blockers, renin inhibitors, ACE inhibitors or ARBs); what is most important is how effectively the overall impact of angiotensin II is blunted. A second new concept is that the complementary actions of RAS blockers and calcium-channel blockers are best explained on the basis of diminished intracellular calcium availability in excitable tissue (sympathetic neurons and vascular smooth muscle cells) via parallel actions that reduce angiotensin II type-1 receptor stimulation and L-channel-mediated calcium flux. Aliskiren is the first of the direct renin inhibitors, the newest subclass of RAS blockers. In both short- and long-term studies, aliskiren has been shown to be similar in efficacy and tolerability compared with other RAS blockers, with the added benefit that its effects persist longer. Outcome studies with aliskiren are currently underway." @default.
• W1994102885 created "2016-06-24" @default.
• W1994102885 creator A5042772507 @default.
• W1994102885 creator A5081529952 @default.
• W1994102885 date "2011-04-01" @default.
• W1994102885 modified "2023-09-26" @default.
• W1994102885 title "Combination therapy with aliskiren and amlodipine in hypertension: treatment rationale and clinical results" @default.
• W1994102885 cites W1967206729 @default.
• W1994102885 cites W1974906889 @default.
• W1994102885 cites W1982235835 @default.
• W1994102885 cites W1982387835 @default.
• W1994102885 cites W1984299707 @default.
• W1994102885 cites W1988716175 @default.
• W1994102885 cites W1994079702 @default.
• W1994102885 cites W2023905894 @default.
• W1994102885 cites W2049323479 @default.
• W1994102885 cites W2052105262 @default.
• W1994102885 cites W2053816472 @default.
• W1994102885 cites W2061749460 @default.
• W1994102885 cites W2070768175 @default.
• W1994102885 cites W2071506321 @default.
• W1994102885 cites W2072785882 @default.
• W1994102885 cites W2100478740 @default.
• W1994102885 cites W2106982105 @default.
• W1994102885 cites W2108000435 @default.
• W1994102885 cites W2108679157 @default.
• W1994102885 cites W2109876426 @default.
• W1994102885 cites W2110880027 @default.
• W1994102885 cites W2115479774 @default.
• W1994102885 cites W2117083889 @default.
• W1994102885 cites W2118795360 @default.
• W1994102885 cites W2124032410 @default.
• W1994102885 cites W2127476874 @default.
• W1994102885 cites W2129991662 @default.
• W1994102885 cites W2137177722 @default.
• W1994102885 cites W2137704829 @default.
• W1994102885 cites W2140626692 @default.
• W1994102885 cites W2147804563 @default.
• W1994102885 cites W2152798629 @default.
• W1994102885 cites W2155934428 @default.
• W1994102885 cites W2156121263 @default.
• W1994102885 cites W2167133324 @default.
• W1994102885 cites W2168907840 @default.
• W1994102885 cites W2172164753 @default.
• W1994102885 cites W2462865984 @default.
• W1994102885 cites W2480651174 @default.
• W1994102885 doi "https://doi.org/10.1586/erc.11.23" @default.
• W1994102885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21417713" @default.
• W1994102885 hasPublicationYear "2011" @default.
• W1994102885 type Work @default.
• W1994102885 sameAs 1994102885 @default.
• W1994102885 citedByCount "3" @default.
• W1994102885 countsByYear W19941028852012 @default.
• W1994102885 countsByYear W19941028852013 @default.
• W1994102885 crossrefType "journal-article" @default.
• W1994102885 hasAuthorship W1994102885A5042772507 @default.
• W1994102885 hasAuthorship W1994102885A5081529952 @default.
• W1994102885 hasConcept C126322002 @default.
• W1994102885 hasConcept C134018914 @default.
• W1994102885 hasConcept C170493617 @default.
• W1994102885 hasConcept C197934379 @default.
• W1994102885 hasConcept C198710026 @default.
• W1994102885 hasConcept C2776999253 @default.
• W1994102885 hasConcept C2778375690 @default.
• W1994102885 hasConcept C2778468042 @default.
• W1994102885 hasConcept C2779646130 @default.
• W1994102885 hasConcept C2779838083 @default.
• W1994102885 hasConcept C2779918671 @default.
• W1994102885 hasConcept C2780356492 @default.
• W1994102885 hasConcept C519063684 @default.
• W1994102885 hasConcept C71924100 @default.
• W1994102885 hasConcept C84393581 @default.
• W1994102885 hasConcept C85520022 @default.
• W1994102885 hasConcept C98274493 @default.
• W1994102885 hasConceptScore W1994102885C126322002 @default.
• W1994102885 hasConceptScore W1994102885C134018914 @default.
• W1994102885 hasConceptScore W1994102885C170493617 @default.
• W1994102885 hasConceptScore W1994102885C197934379 @default.
• W1994102885 hasConceptScore W1994102885C198710026 @default.
• W1994102885 hasConceptScore W1994102885C2776999253 @default.
• W1994102885 hasConceptScore W1994102885C2778375690 @default.
• W1994102885 hasConceptScore W1994102885C2778468042 @default.
• W1994102885 hasConceptScore W1994102885C2779646130 @default.
• W1994102885 hasConceptScore W1994102885C2779838083 @default.
• W1994102885 hasConceptScore W1994102885C2779918671 @default.
• W1994102885 hasConceptScore W1994102885C2780356492 @default.
• W1994102885 hasConceptScore W1994102885C519063684 @default.
• W1994102885 hasConceptScore W1994102885C71924100 @default.
• W1994102885 hasConceptScore W1994102885C84393581 @default.
• W1994102885 hasConceptScore W1994102885C85520022 @default.
• W1994102885 hasConceptScore W1994102885C98274493 @default.
• W1994102885 hasIssue "4" @default.
• W1994102885 hasLocation W19941028851 @default.
• W1994102885 hasLocation W19941028852 @default.
• W1994102885 hasOpenAccess W1994102885 @default.
• W1994102885 hasPrimaryLocation W19941028851 @default.
• W1994102885 hasRelatedWork W1899303 @default.
• W1994102885 hasRelatedWork W1994102885 @default.

• next