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- W1994105347 abstract "Recent evidence suggests that FK506, a newly developed immunosuppressant, has protective effects against cerebral ischemia. The purpose of this study was to assess the effects of FK506 when given in the recirculation period following transient focal ischemia. We subjected rats to 2 hrs of middle cerebral artery occlusion, using an intraluminal filament technique, and allowed 48 hrs of reperfusion. FK506 (1.0 mg kg−1) was injected intravenously at 1 hr or 3 hrs after the start of recirculation. Infarct volume was evaluated by 2,3,5-triphenyltetrazolium chloride (TTC) staining. FK506 markedly reduced infarct volume when given after 1 hr of reirculation but had no significant effect when given after 3 hrs. These results suggest that FK506 has protective effects against brain damage due to transient focal ischemia, even when administered after the ischemic periods." @default.
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- W1994105347 date "1996-09-01" @default.
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- W1994105347 title "Postischemic administration of FK506 reduces infarct volume following transient focal brain ischemia" @default.
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- W1994105347 doi "https://doi.org/10.1002/(sici)1520-6769(199609)19:2<83::aid-nrc167>3.0.co;2-v" @default.
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