FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994116955> ?p ?o ?g. }

• W1994116955 endingPage "166" @default.
• W1994116955 startingPage "160" @default.
• W1994116955 abstract "AFAR genes play a key role in the detoxification of the carcinogen Aflatoxin B(1) (AFB(1)). In the rat, Afar1 induction can prevent AFB(1)-induced liver cancer. It has been proposed that AFAR enzymes can metabolise endogenous diketones and dialdehydes that may be cytotoxic and/or genotoxic. Furthermore, human AFAR1 catalyses the rate limiting step in the synthesis of the neuromodulator gamma-hydroxybutyrate (GHB) and was found elevated in neurodegenerative diseases such as Alzheimer's and dementia with Lewy bodies (DLB). The human AFAR gene family maps to a genomic region in 1p36 of frequent hemizygous deletions in various human cancers. To investigate, if genetic variation of AFAR1 and AFAR2 exists that may alter protein detoxification capabilities and confer susceptibility to cancer, we have analysed a spectrum of human tumours and tumour cell lines for genetic heterogeneity. From 110 DNA samples, we identified nine different amino acid changes; two were in AFAR1 and seven in AFAR2. In AFAR1, we found genetic variation in the proposed substrate-binding amino acid 113, encoding Ala(113) or Thr(113). An AFAR2 variant had a Glu(55) substituted by Lys(55) at a position that is conserved among many aldo-keto reductases. This polarity change may have an effect on the proposed substrate binding amino acids nearby (Met(47), Tyr(48), Asp(50)). Further population analyses and functional studies of the nine variants detected may show if these variants are disease-related." @default.
• W1994116955 created "2016-06-24" @default.
• W1994116955 creator A5034994477 @default.
• W1994116955 creator A5036629034 @default.
• W1994116955 creator A5039907821 @default.
• W1994116955 creator A5051618572 @default.
• W1994116955 creator A5062139994 @default.
• W1994116955 creator A5069810248 @default.
• W1994116955 creator A5075724418 @default.
• W1994116955 creator A5081816422 @default.
• W1994116955 date "2008-12-01" @default.
• W1994116955 modified "2023-10-05" @default.
• W1994116955 title "Genetic variation of Aflatoxin B1 aldehyde reductase genes (AFAR) in human tumour cells" @default.
• W1994116955 cites W1521238629 @default.
• W1994116955 cites W1593719909 @default.
• W1994116955 cites W1770562442 @default.
• W1994116955 cites W1846205077 @default.
• W1994116955 cites W1921020344 @default.
• W1994116955 cites W1979649961 @default.
• W1994116955 cites W1984423513 @default.
• W1994116955 cites W1985455449 @default.
• W1994116955 cites W1992387060 @default.
• W1994116955 cites W1999057078 @default.
• W1994116955 cites W2004975163 @default.
• W1994116955 cites W2023595441 @default.
• W1994116955 cites W2044423659 @default.
• W1994116955 cites W2048912521 @default.
• W1994116955 cites W2067349072 @default.
• W1994116955 cites W2080482503 @default.
• W1994116955 cites W2088108576 @default.
• W1994116955 cites W2103803271 @default.
• W1994116955 cites W2107410297 @default.
• W1994116955 cites W2163172441 @default.
• W1994116955 cites W2168251468 @default.
• W1994116955 doi "https://doi.org/10.1016/j.canlet.2008.07.013" @default.
• W1994116955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18752886" @default.
• W1994116955 hasPublicationYear "2008" @default.
• W1994116955 type Work @default.
• W1994116955 sameAs 1994116955 @default.
• W1994116955 citedByCount "10" @default.
• W1994116955 countsByYear W19941169552012 @default.
• W1994116955 countsByYear W19941169552013 @default.
• W1994116955 countsByYear W19941169552014 @default.
• W1994116955 countsByYear W19941169552015 @default.
• W1994116955 countsByYear W19941169552016 @default.
• W1994116955 countsByYear W19941169552021 @default.
• W1994116955 crossrefType "journal-article" @default.
• W1994116955 hasAuthorship W1994116955A5034994477 @default.
• W1994116955 hasAuthorship W1994116955A5036629034 @default.
• W1994116955 hasAuthorship W1994116955A5039907821 @default.
• W1994116955 hasAuthorship W1994116955A5051618572 @default.
• W1994116955 hasAuthorship W1994116955A5062139994 @default.
• W1994116955 hasAuthorship W1994116955A5069810248 @default.
• W1994116955 hasAuthorship W1994116955A5075724418 @default.
• W1994116955 hasAuthorship W1994116955A5081816422 @default.
• W1994116955 hasConcept C104317684 @default.
• W1994116955 hasConcept C114246631 @default.
• W1994116955 hasConcept C134651460 @default.
• W1994116955 hasConcept C144024400 @default.
• W1994116955 hasConcept C149923435 @default.
• W1994116955 hasConcept C181199279 @default.
• W1994116955 hasConcept C2908647359 @default.
• W1994116955 hasConcept C31903555 @default.
• W1994116955 hasConcept C40758303 @default.
• W1994116955 hasConcept C515207424 @default.
• W1994116955 hasConcept C54355233 @default.
• W1994116955 hasConcept C55493867 @default.
• W1994116955 hasConcept C68873052 @default.
• W1994116955 hasConcept C86803240 @default.
• W1994116955 hasConceptScore W1994116955C104317684 @default.
• W1994116955 hasConceptScore W1994116955C114246631 @default.
• W1994116955 hasConceptScore W1994116955C134651460 @default.
• W1994116955 hasConceptScore W1994116955C144024400 @default.
• W1994116955 hasConceptScore W1994116955C149923435 @default.
• W1994116955 hasConceptScore W1994116955C181199279 @default.
• W1994116955 hasConceptScore W1994116955C2908647359 @default.
• W1994116955 hasConceptScore W1994116955C31903555 @default.
• W1994116955 hasConceptScore W1994116955C40758303 @default.
• W1994116955 hasConceptScore W1994116955C515207424 @default.
• W1994116955 hasConceptScore W1994116955C54355233 @default.
• W1994116955 hasConceptScore W1994116955C55493867 @default.
• W1994116955 hasConceptScore W1994116955C68873052 @default.
• W1994116955 hasConceptScore W1994116955C86803240 @default.
• W1994116955 hasIssue "1" @default.
• W1994116955 hasLocation W19941169551 @default.
• W1994116955 hasLocation W19941169552 @default.
• W1994116955 hasOpenAccess W1994116955 @default.
• W1994116955 hasPrimaryLocation W19941169551 @default.
• W1994116955 hasRelatedWork W1563004741 @default.
• W1994116955 hasRelatedWork W1644178486 @default.
• W1994116955 hasRelatedWork W1994905442 @default.
• W1994116955 hasRelatedWork W2000140281 @default.
• W1994116955 hasRelatedWork W2004312381 @default.
• W1994116955 hasRelatedWork W2022676069 @default.
• W1994116955 hasRelatedWork W2043151771 @default.
• W1994116955 hasRelatedWork W2071806336 @default.
• W1994116955 hasRelatedWork W2083360052 @default.
• W1994116955 hasRelatedWork W59179329 @default.

• next