Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994119070> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1994119070 endingPage "56" @default.
- W1994119070 startingPage "53" @default.
- W1994119070 abstract "To determine whether selectivity for serotonin reuptake plays a role in antidepressant-associated mania (AAM), we evaluated the frequency of treatment-emergent mania in patients with unipolar depression who received either citalopram, a highly selective serotonin uptake inhibitor, or the adrenergic tetracyclic antidepressants (TTCAs) maproriline and mianserin, or placebo. Data were collected from post-marketing reports of adverse events, three placebo-controlled trials and four double-blind comparative trials. Of the total 4,004 depressed patients treated with citalopram (2482 from postmarketing data, 840 from placebo-controlled studies and 682 from TTCAs comparative studies), 25 (0.62%) had manic episodes. The rate of AAM in the comparative trials was significantly lower in the citalopram-treated patients (1/682, 0.15%) than in the TTCA-treated patients (5/389, 1.29%) (P = 0.03). In the placebo-controlled studies, no manic episodes were reported in the patients given placebo, but one manic episode occurred in a citalopram-treated patient (1/840, 0.12%). The citalopram-treated patients in whom AAM developed were significantly older than those in whom it did not (about 10 years, P < 0.001); gender distribution was similar. In conclusion, despite its limitations, our study apparently indicates that citalopram, a highly selective serotonin reuptake inhibitor, is associated with a significantly lower rate of treatment-emergent manic episodes than TTCAs, which have noradrenergic activity, but a similar rate to that reported for less selective SSRIs." @default.
- W1994119070 created "2016-06-24" @default.
- W1994119070 creator A5058095179 @default.
- W1994119070 creator A5069052236 @default.
- W1994119070 creator A5079791775 @default.
- W1994119070 date "2000-01-01" @default.
- W1994119070 modified "2023-10-15" @default.
- W1994119070 title "Is selectivity for serotonin uptake associated with a reduced emergence of manic episodes in depressed patients?" @default.
- W1994119070 doi "https://doi.org/10.1097/00004850-200015010-00009" @default.
- W1994119070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10836288" @default.
- W1994119070 hasPublicationYear "2000" @default.
- W1994119070 type Work @default.
- W1994119070 sameAs 1994119070 @default.
- W1994119070 citedByCount "16" @default.
- W1994119070 countsByYear W19941190702012 @default.
- W1994119070 countsByYear W19941190702013 @default.
- W1994119070 countsByYear W19941190702014 @default.
- W1994119070 countsByYear W19941190702020 @default.
- W1994119070 countsByYear W19941190702021 @default.
- W1994119070 crossrefType "journal-article" @default.
- W1994119070 hasAuthorship W1994119070A5058095179 @default.
- W1994119070 hasAuthorship W1994119070A5069052236 @default.
- W1994119070 hasAuthorship W1994119070A5079791775 @default.
- W1994119070 hasConcept C118552586 @default.
- W1994119070 hasConcept C126322002 @default.
- W1994119070 hasConcept C142724271 @default.
- W1994119070 hasConcept C15744967 @default.
- W1994119070 hasConcept C170493617 @default.
- W1994119070 hasConcept C204787440 @default.
- W1994119070 hasConcept C27081682 @default.
- W1994119070 hasConcept C2775864247 @default.
- W1994119070 hasConcept C2776134451 @default.
- W1994119070 hasConcept C2776174506 @default.
- W1994119070 hasConcept C2776809841 @default.
- W1994119070 hasConcept C2777490545 @default.
- W1994119070 hasConcept C2778541603 @default.
- W1994119070 hasConcept C2779177272 @default.
- W1994119070 hasConcept C2780092697 @default.
- W1994119070 hasConcept C2780756443 @default.
- W1994119070 hasConcept C2780831388 @default.
- W1994119070 hasConcept C2781161787 @default.
- W1994119070 hasConcept C31487548 @default.
- W1994119070 hasConcept C42219234 @default.
- W1994119070 hasConcept C71924100 @default.
- W1994119070 hasConceptScore W1994119070C118552586 @default.
- W1994119070 hasConceptScore W1994119070C126322002 @default.
- W1994119070 hasConceptScore W1994119070C142724271 @default.
- W1994119070 hasConceptScore W1994119070C15744967 @default.
- W1994119070 hasConceptScore W1994119070C170493617 @default.
- W1994119070 hasConceptScore W1994119070C204787440 @default.
- W1994119070 hasConceptScore W1994119070C27081682 @default.
- W1994119070 hasConceptScore W1994119070C2775864247 @default.
- W1994119070 hasConceptScore W1994119070C2776134451 @default.
- W1994119070 hasConceptScore W1994119070C2776174506 @default.
- W1994119070 hasConceptScore W1994119070C2776809841 @default.
- W1994119070 hasConceptScore W1994119070C2777490545 @default.
- W1994119070 hasConceptScore W1994119070C2778541603 @default.
- W1994119070 hasConceptScore W1994119070C2779177272 @default.
- W1994119070 hasConceptScore W1994119070C2780092697 @default.
- W1994119070 hasConceptScore W1994119070C2780756443 @default.
- W1994119070 hasConceptScore W1994119070C2780831388 @default.
- W1994119070 hasConceptScore W1994119070C2781161787 @default.
- W1994119070 hasConceptScore W1994119070C31487548 @default.
- W1994119070 hasConceptScore W1994119070C42219234 @default.
- W1994119070 hasConceptScore W1994119070C71924100 @default.
- W1994119070 hasIssue "1" @default.
- W1994119070 hasLocation W19941190701 @default.
- W1994119070 hasLocation W19941190702 @default.
- W1994119070 hasOpenAccess W1994119070 @default.
- W1994119070 hasPrimaryLocation W19941190701 @default.
- W1994119070 hasRelatedWork W1608131920 @default.
- W1994119070 hasRelatedWork W1994119070 @default.
- W1994119070 hasRelatedWork W2014104788 @default.
- W1994119070 hasRelatedWork W2040285006 @default.
- W1994119070 hasRelatedWork W2067493036 @default.
- W1994119070 hasRelatedWork W2128281042 @default.
- W1994119070 hasRelatedWork W2296890278 @default.
- W1994119070 hasRelatedWork W2408256799 @default.
- W1994119070 hasRelatedWork W4236621477 @default.
- W1994119070 hasRelatedWork W4283362117 @default.
- W1994119070 hasVolume "15" @default.
- W1994119070 isParatext "false" @default.
- W1994119070 isRetracted "false" @default.
- W1994119070 magId "1994119070" @default.
- W1994119070 workType "article" @default.