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• W1994139780 endingPage "242" @default.
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• W1994139780 abstract "Increased expression of Na+/H+ exchanger (NHE) and Na+,K+-ATPase activity have been demonstrated in diabetic nephropathy and are implicated in the development of hypertension. The aim of this study was to investigate the effect of a synthetic manganese porphyrin SOD mimic and peroxynitrite scavenger, Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin (MnTM-2-PyP) on the expression of NHE and Na+,K+-ATPase activity in the kidneys of streptozotocin (STZ) diabetic rats. MnTM-2-PyP administration (1 mg/kg/day) started immediately after STZ and lasted 2 months. Glucose and glycosylated hemoglobin levels were measured in blood. NHE-1 and NHE-3 isoform expression, Na+,K+-ATPase activity, and markers of ROS/RNS-induced damage were determined in kidney homogenates. Diabetes caused lipid peroxidation, inactivation of aconitase, and increase of nitrotyrosine, which paralleled an increase in NHE-1 and NHE-3 expression and Na+,K+-ATPase activity. MnTM-2-PyP treatment had no effect on blood glucose and glycosylated hemoglobin, but suppressed lipid peroxidation and nitrotyrosine, protected aconitase against inactivation, and reversed the induction of NHE-1 and NHE-3 isoforms. Na+/H+ exchanger is under the control of redox-based cellular transcriptional activity, including members of the SP family of transcription factors. Mn(III) alkylpyridylporphyrins were previously found to inhibit activation of major transcription factors, including SP-1 via scavenging of signaling ROS/RNS. Therefore, our data suggest that, by reducing the levels of ROS/RNS, MnTM-2-PyP might interfere with signaling pathways responsible for NHE up-regulation." @default.
• W1994139780 created "2016-06-24" @default.
• W1994139780 creator A5009276853 @default.
• W1994139780 creator A5051831713 @default.
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• W1994139780 date "2009-12-01" @default.
• W1994139780 modified "2023-10-17" @default.
• W1994139780 title "Effect of potent redox-modulating manganese porphyrin, MnTM-2-PyP, on the Na⁺/H⁺exchangers NHE-1 and NHE-3 in the diabetic rat" @default.
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• W1994139780 doi "https://doi.org/10.1179/135100009x12525712409698" @default.
• W1994139780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20003708" @default.
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