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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994140756> ?p ?o ?g. }

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• W1994140756 abstract "Structure-guided de novo drug design led to the identification of a novel series of substituted pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors. Pyridine carboxyamide derivatives bearing a substituted aryl group at the 5-position of the pyridine ring show appreciable activity, while constraining the side chain by placing a pyrazole carboxylic acid generated a potent lead series with consistent activity against EGLN-1." @default.
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• W1994140756 date "2006-11-01" @default.
• W1994140756 modified "2023-10-18" @default.
• W1994140756 title "Design and synthesis of substituted pyridine derivatives as HIF-1α prolyl hydroxylase inhibitors" @default.
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• W1994140756 doi "https://doi.org/10.1016/j.bmcl.2006.08.026" @default.
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