Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994140988> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W1994140988 endingPage "23???32" @default.
- W1994140988 startingPage "23???32" @default.
- W1994140988 abstract "In contrast to studies in isolated blood vessels, results from whole-animal studies are ambiguous regarding differences in pressor responsiveness between spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats, possibly related to the measurement of blood pressure instead of total peripheral resistance (TPR) and to differences in compensatory mechanisms.We evaluated responses of blood pressure and TPR to two doses of the alpha 1-agonist phenylephrine during the development of hypertension and cardiovascular hypertrophy in SHR aged 8-26 weeks compared with age-matched WKY rats before and after ganglionic blockade. At 16 weeks of age more-complete dose-response curves to the alpha 1-agonist methoxamine were also constructed.Over the age range studied, the SHR developed marked hypertension, related to a significant rise in TPR, and concomitantly significant cardiac hypertrophy, as well as hypertrophy of the mesenteric arterial bed. The blood pressure responses to phenylephrine were diminished in the SHR compared with the WKY rats at all ages studied, but this effect was significant only in the absence of ganglionic blockade. TPR responses were significantly less in the SHR than in the WKY rats, both with and without concomitant ganglionic blockade. In contrast, both blood pressure and TPR responses to low doses, but not higher doses, of methoxamine were enhanced in the SHR compared with the WKY rats.These results indicate that the development of hypertension in SHR in vivo is associated with variable changes in blood pressure and TPR responses to alpha 1-receptor stimulation, depending on the alpha 1-agonist employed." @default.
- W1994140988 created "2016-06-24" @default.
- W1994140988 creator A5002739810 @default.
- W1994140988 creator A5013474083 @default.
- W1994140988 creator A5027627332 @default.
- W1994140988 creator A5035096656 @default.
- W1994140988 date "1994-01-01" @default.
- W1994140988 modified "2023-09-23" @default.
- W1994140988 title "Arterial hypertrophy and pressor responsiveness during development of hypertension in spontaneously hypertensive rats" @default.
- W1994140988 doi "https://doi.org/10.1097/00004872-199401000-00005" @default.
- W1994140988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7908913" @default.
- W1994140988 hasPublicationYear "1994" @default.
- W1994140988 type Work @default.
- W1994140988 sameAs 1994140988 @default.
- W1994140988 citedByCount "25" @default.
- W1994140988 countsByYear W19941409882013 @default.
- W1994140988 countsByYear W19941409882020 @default.
- W1994140988 crossrefType "journal-article" @default.
- W1994140988 hasAuthorship W1994140988A5002739810 @default.
- W1994140988 hasAuthorship W1994140988A5013474083 @default.
- W1994140988 hasAuthorship W1994140988A5027627332 @default.
- W1994140988 hasAuthorship W1994140988A5035096656 @default.
- W1994140988 hasConcept C126322002 @default.
- W1994140988 hasConcept C134018914 @default.
- W1994140988 hasConcept C167414201 @default.
- W1994140988 hasConcept C170493617 @default.
- W1994140988 hasConcept C2777952589 @default.
- W1994140988 hasConcept C2778086073 @default.
- W1994140988 hasConcept C2778938600 @default.
- W1994140988 hasConcept C2780745239 @default.
- W1994140988 hasConcept C71924100 @default.
- W1994140988 hasConcept C84393581 @default.
- W1994140988 hasConceptScore W1994140988C126322002 @default.
- W1994140988 hasConceptScore W1994140988C134018914 @default.
- W1994140988 hasConceptScore W1994140988C167414201 @default.
- W1994140988 hasConceptScore W1994140988C170493617 @default.
- W1994140988 hasConceptScore W1994140988C2777952589 @default.
- W1994140988 hasConceptScore W1994140988C2778086073 @default.
- W1994140988 hasConceptScore W1994140988C2778938600 @default.
- W1994140988 hasConceptScore W1994140988C2780745239 @default.
- W1994140988 hasConceptScore W1994140988C71924100 @default.
- W1994140988 hasConceptScore W1994140988C84393581 @default.
- W1994140988 hasIssue "1" @default.
- W1994140988 hasLocation W19941409881 @default.
- W1994140988 hasLocation W19941409882 @default.
- W1994140988 hasOpenAccess W1994140988 @default.
- W1994140988 hasPrimaryLocation W19941409881 @default.
- W1994140988 hasRelatedWork W1965781866 @default.
- W1994140988 hasRelatedWork W1974520470 @default.
- W1994140988 hasRelatedWork W1992842231 @default.
- W1994140988 hasRelatedWork W1994140988 @default.
- W1994140988 hasRelatedWork W2027913950 @default.
- W1994140988 hasRelatedWork W2101411396 @default.
- W1994140988 hasRelatedWork W2163966674 @default.
- W1994140988 hasRelatedWork W2165958118 @default.
- W1994140988 hasRelatedWork W2171089442 @default.
- W1994140988 hasRelatedWork W2398697207 @default.
- W1994140988 hasVolume "12" @default.
- W1994140988 isParatext "false" @default.
- W1994140988 isRetracted "false" @default.
- W1994140988 magId "1994140988" @default.
- W1994140988 workType "article" @default.