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- W1994142130 endingPage "1909" @default.
- W1994142130 startingPage "1902" @default.
- W1994142130 abstract "Identification and validation of protein targets of bioactive small molecules is an important problem in chemical biology and drug discovery. Currently, no single method is satisfactory for this task. Here, we provide an overview of common methods for target identification and validation that historically were most successful. We have classified for the first time the existing methods into two distinct and complementary types, the 'top-down' and 'bottom-up' approaches. In a typical top-down approach, the cellular phenotype is used as a starting point and the molecular target is approached through systematic narrowing down of possibilities by taking advantage of the detailed existing knowledge of cellular pathways and processes. In contrast, the bottom-up approach entails the direct detection and identification of the molecular targets using affinity-based or genetic methods. A special emphasis is placed on target validation, including correlation analysis and genetic methods, as this area is often ignored despite its importance." @default.
- W1994142130 created "2016-06-24" @default.
- W1994142130 creator A5013227164 @default.
- W1994142130 creator A5015479608 @default.
- W1994142130 date "2012-03-01" @default.
- W1994142130 modified "2023-10-12" @default.
- W1994142130 title "Identification and validation of protein targets of bioactive small molecules" @default.
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