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• W1994143386 abstract "Different intrinsic properties of the constituent cells of the anterior cruciate ligament (ACL) and medial collateral ligament (MCL) have been proposed as factors involved in the differential repair mechanisms in these ligaments. To examine this hypothesis, we established primary cell lines from tissue explants. The outgrowth of cells from ACL explants was slower than that from MCL explants. The growth curves of ACL and MCL cultures at both passages 2 and 6 showed a slower rate of proliferation of ACL cells than of MCL cells ( P < 0.005). DNA synthesis supports the conclusion that these cells have differential proliferation rates in culture. An in vitro wound closure assay was performed by creating a uniform wound of 0.6-mm width in the confluent layer of ACL and MCL cultures. By 48 h post-wounding, cellfree zones created in ACL cultures were partially occupied by single cells in a non-confluent fashion. In contrast, the wounded zone in the MCL cultures was almost completely covered by the cells. Growth factors have been demonstrated to have both mitogenic and metabolic effects on cell cultures. We investigated the possible proliferative response of the ACL and MCL to growth factors, and we analyzed the in vitro effects of basic fibroblast growth factor (b-FGF) and transforming growth factor-β (TGF-β) on fibroblast cell cultures obtained from rabbit knee ligaments. Neither b-FGF nor β had any significant effect on the cell proliferation of ACL and MCL cultures after 48h. However, TGF-β did have an inhibitory effect on thymidine incorporation, especially at concentrations greater than i ng/ml, while b-FGF stimulated thymidine incorporation in ACL and MCL fibroblasts in a dose-dependent manner, b-FGF altered the cell phenotype to an elongated form, which suggests stimulation of cell migration. This in vitro study implies a potential use for growth factors in the treatment of ACL and MCL injuries in vivo." @default.
• W1994143386 created "2016-06-24" @default.
• W1994143386 creator A5015075213 @default.
• W1994143386 date "1996-03-01" @default.
• W1994143386 modified "2023-09-27" @default.
• W1994143386 title "Intrinsic properties of anterior cruciate ligament (ACL) and medial collateral ligament (MCL) cells and their responses to growth factors (bFGF and TGF-β): An in vitro cell culture study" @default.
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• W1994143386 doi "https://doi.org/10.1007/bf02348808" @default.
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