Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994147209> ?p ?o ?g. }
- W1994147209 endingPage "1053" @default.
- W1994147209 startingPage "1045" @default.
- W1994147209 abstract "We investigated how serotonergic neurotransmission was affected by 6-hydroxydopamine (6-OHDA) lesioning of the adult rat brain dopamine (DA) system. In this animal model for Parkinson's disease (PD), the effect of destroying ascending DA pathways on extracellular levels of serotonin (5-HT) and 5-HT innervation in rat striatum were examined. Profound unilateral lesions of the nigrostriatal DA pathways were made by infusing 6-OHDA unilaterally into either the right medial forebrain bundle or the right substantia nigra. At 5 weeks after lesioning extracellular levels of DA and 5-HT were determined with microdialysis and high-pressure liquid chromatography under basal conditions and after systemic injections of apomorphine or amphetamine. DA nerve-terminal destruction and 5-HT innervation were determined with quantitative autoradiography. 6-OHDA lesioning reduced extracellular levels of DA below detection limits and led to statistically significant increases in extracellular 5-HT. Apomorphine, and amphetamine, respectively increased extracellular 5-HT to 8.2- and 2.2-fold above baseline levels in intact animals; these effects were absent in 6-OHDA-lesioned animals. Basal levels of [(3)H]paroxetine binding to 5-HT transporters in caudate-putamen increased by 41% in 6-OHDA-lesioned animals. These results suggest that 6-OHDA lesioning led to hyperinnervation of 5-HT nerve terminals and increases in basal extracellular 5-HT levels, but also to an unexplained loss of apomorphine and amphetamine-induced release of 5-HT. Addressing whether this impairment has significance in the onset of PD might lead to development of new strategies to manage parkinsonian symptoms." @default.
- W1994147209 created "2016-06-24" @default.
- W1994147209 creator A5030394267 @default.
- W1994147209 creator A5045811361 @default.
- W1994147209 creator A5081640744 @default.
- W1994147209 date "2003-07-01" @default.
- W1994147209 modified "2023-10-16" @default.
- W1994147209 title "Dopamine depletion abolishes apomorphine- and amphetamine-induced increases in extracellular serotonin levels in the striatum of conscious rats: a microdialysis study" @default.
- W1994147209 cites W1582206225 @default.
- W1994147209 cites W1679288996 @default.
- W1994147209 cites W1902740936 @default.
- W1994147209 cites W1943060734 @default.
- W1994147209 cites W1965960974 @default.
- W1994147209 cites W1970518640 @default.
- W1994147209 cites W1980032093 @default.
- W1994147209 cites W1980093205 @default.
- W1994147209 cites W1993889973 @default.
- W1994147209 cites W1995589306 @default.
- W1994147209 cites W1997141130 @default.
- W1994147209 cites W1997260025 @default.
- W1994147209 cites W2000624476 @default.
- W1994147209 cites W2001418018 @default.
- W1994147209 cites W2006285647 @default.
- W1994147209 cites W2007027960 @default.
- W1994147209 cites W2007247016 @default.
- W1994147209 cites W2009085945 @default.
- W1994147209 cites W2009874687 @default.
- W1994147209 cites W2016263370 @default.
- W1994147209 cites W2019424998 @default.
- W1994147209 cites W2020559806 @default.
- W1994147209 cites W2030719127 @default.
- W1994147209 cites W2030747609 @default.
- W1994147209 cites W2032988440 @default.
- W1994147209 cites W2033297210 @default.
- W1994147209 cites W2034979868 @default.
- W1994147209 cites W2037506390 @default.
- W1994147209 cites W2038874217 @default.
- W1994147209 cites W2040635024 @default.
- W1994147209 cites W2048034172 @default.
- W1994147209 cites W2057879372 @default.
- W1994147209 cites W2057960577 @default.
- W1994147209 cites W2061749100 @default.
- W1994147209 cites W2065258666 @default.
- W1994147209 cites W2066113689 @default.
- W1994147209 cites W2067787254 @default.
- W1994147209 cites W2069132461 @default.
- W1994147209 cites W2070652361 @default.
- W1994147209 cites W2071257655 @default.
- W1994147209 cites W2071305706 @default.
- W1994147209 cites W2075116326 @default.
- W1994147209 cites W2077557343 @default.
- W1994147209 cites W2079736317 @default.
- W1994147209 cites W2089148759 @default.
- W1994147209 cites W2090608831 @default.
- W1994147209 cites W2090715212 @default.
- W1994147209 cites W2091764078 @default.
- W1994147209 cites W2109322747 @default.
- W1994147209 cites W2120660227 @default.
- W1994147209 cites W2121848941 @default.
- W1994147209 cites W2129083538 @default.
- W1994147209 cites W2139921727 @default.
- W1994147209 cites W2143959688 @default.
- W1994147209 cites W2328511817 @default.
- W1994147209 doi "https://doi.org/10.1016/s0306-4522(03)00219-7" @default.
- W1994147209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12831863" @default.
- W1994147209 hasPublicationYear "2003" @default.
- W1994147209 type Work @default.
- W1994147209 sameAs 1994147209 @default.
- W1994147209 citedByCount "42" @default.
- W1994147209 countsByYear W19941472092012 @default.
- W1994147209 countsByYear W19941472092013 @default.
- W1994147209 countsByYear W19941472092014 @default.
- W1994147209 countsByYear W19941472092015 @default.
- W1994147209 countsByYear W19941472092017 @default.
- W1994147209 countsByYear W19941472092018 @default.
- W1994147209 countsByYear W19941472092021 @default.
- W1994147209 crossrefType "journal-article" @default.
- W1994147209 hasAuthorship W1994147209A5030394267 @default.
- W1994147209 hasAuthorship W1994147209A5045811361 @default.
- W1994147209 hasAuthorship W1994147209A5081640744 @default.
- W1994147209 hasConcept C126322002 @default.
- W1994147209 hasConcept C134018914 @default.
- W1994147209 hasConcept C137183658 @default.
- W1994147209 hasConcept C170493617 @default.
- W1994147209 hasConcept C185592680 @default.
- W1994147209 hasConcept C2775864247 @default.
- W1994147209 hasConcept C2776669363 @default.
- W1994147209 hasConcept C2777193897 @default.
- W1994147209 hasConcept C2777525119 @default.
- W1994147209 hasConcept C2780062018 @default.
- W1994147209 hasConcept C2780938664 @default.
- W1994147209 hasConcept C28406088 @default.
- W1994147209 hasConcept C37000724 @default.
- W1994147209 hasConcept C50156730 @default.
- W1994147209 hasConcept C513476851 @default.
- W1994147209 hasConcept C55493867 @default.
- W1994147209 hasConcept C71924100 @default.
- W1994147209 hasConceptScore W1994147209C126322002 @default.