Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994148625> ?p ?o ?g. }
- W1994148625 endingPage "1144" @default.
- W1994148625 startingPage "1124" @default.
- W1994148625 abstract "Dichloroacetate (DCA) exerts multiple effects on pathways of intermediary metabolism. It stimulates peripheral glucose utilization and inhibits gluconeogeneis, thereby reducing hyperglycemia in animals and humans with diabetes mellitus. It inhibits lipogenesis and cholesterolgenesis, thereby decreasing circulating lipid and lipoprotein levels in short-term studies in patients with acquired or hereditary disorders of lipoprotein metabolism. By stimulating the activity of pyruvate dehydrogenase, DCA facilitates oxidation of lactate and decreases morbidity in acquired and congenital forms of lactic acidosis. The drug improves cardiac output and left ventricular mechanical efficiency under conditions of myocardial ischemia or failure, probably by facilitating myocardial metabolism of carbohydrate and lactate as opposed to fat. DCA may also enhance regional lactate removal and restoration of brain function in experimental states of cerebral ischemia. DCA appears to inhibit its own metabolism, which may influence the duration of its pharmacologic actions and lead to toxicity. DCA can cause a reversible peripheral neuropathy that may be related to thiamine deficiency and may be ameliorated or prevented with thiamine supplementation. Other toxic effects of DCA may be species-specific and reflect marked interspecies variation in pharmacokinetics. Despite its potential toxicity and limited clinical experience, DCA and its derivatives may prove to be useful in probing regulatory aspects of intermediary metabolism and in the acute or chronic treatment of several metabolic disorders." @default.
- W1994148625 created "2016-06-24" @default.
- W1994148625 creator A5080489320 @default.
- W1994148625 date "1989-11-01" @default.
- W1994148625 modified "2023-10-04" @default.
- W1994148625 title "The pharmacology of dichloroacetate" @default.
- W1994148625 cites W13351788 @default.
- W1994148625 cites W144505945 @default.
- W1994148625 cites W1492348364 @default.
- W1994148625 cites W1502351078 @default.
- W1994148625 cites W1504957217 @default.
- W1994148625 cites W1521702354 @default.
- W1994148625 cites W1526333661 @default.
- W1994148625 cites W1537421998 @default.
- W1994148625 cites W1555045548 @default.
- W1994148625 cites W1557783700 @default.
- W1994148625 cites W1567514264 @default.
- W1994148625 cites W1582853869 @default.
- W1994148625 cites W161533123 @default.
- W1994148625 cites W1624705676 @default.
- W1994148625 cites W163280608 @default.
- W1994148625 cites W1757455318 @default.
- W1994148625 cites W1759931938 @default.
- W1994148625 cites W1762209073 @default.
- W1994148625 cites W1764041080 @default.
- W1994148625 cites W1802977969 @default.
- W1994148625 cites W183190858 @default.
- W1994148625 cites W1845254999 @default.
- W1994148625 cites W1872299230 @default.
- W1994148625 cites W1877442256 @default.
- W1994148625 cites W189525828 @default.
- W1994148625 cites W195471417 @default.
- W1994148625 cites W1964072393 @default.
- W1994148625 cites W1964150571 @default.
- W1994148625 cites W1964425027 @default.
- W1994148625 cites W1967137089 @default.
- W1994148625 cites W1969131631 @default.
- W1994148625 cites W1970147297 @default.
- W1994148625 cites W1970854665 @default.
- W1994148625 cites W1972048754 @default.
- W1994148625 cites W1972204675 @default.
- W1994148625 cites W1972277121 @default.
- W1994148625 cites W1973068553 @default.
- W1994148625 cites W1974740182 @default.
- W1994148625 cites W1974889229 @default.
- W1994148625 cites W1975753006 @default.
- W1994148625 cites W1976653606 @default.
- W1994148625 cites W1977043167 @default.
- W1994148625 cites W1978246638 @default.
- W1994148625 cites W1978885288 @default.
- W1994148625 cites W1980730750 @default.
- W1994148625 cites W1981465989 @default.
- W1994148625 cites W1981943883 @default.
- W1994148625 cites W1982971466 @default.
- W1994148625 cites W1983877797 @default.
- W1994148625 cites W1984241073 @default.
- W1994148625 cites W1987090819 @default.
- W1994148625 cites W1987460333 @default.
- W1994148625 cites W1987654201 @default.
- W1994148625 cites W1988247609 @default.
- W1994148625 cites W1988481213 @default.
- W1994148625 cites W1988766441 @default.
- W1994148625 cites W1989278422 @default.
- W1994148625 cites W1989467867 @default.
- W1994148625 cites W1991301443 @default.
- W1994148625 cites W1991335504 @default.
- W1994148625 cites W1991340759 @default.
- W1994148625 cites W1993323237 @default.
- W1994148625 cites W1994050387 @default.
- W1994148625 cites W1995902580 @default.
- W1994148625 cites W1996225323 @default.
- W1994148625 cites W1996529863 @default.
- W1994148625 cites W1996653119 @default.
- W1994148625 cites W1996713055 @default.
- W1994148625 cites W1997343448 @default.
- W1994148625 cites W1998211590 @default.
- W1994148625 cites W1998302616 @default.
- W1994148625 cites W1998490400 @default.
- W1994148625 cites W2000123524 @default.
- W1994148625 cites W2000130071 @default.
- W1994148625 cites W2001077180 @default.
- W1994148625 cites W2002086621 @default.
- W1994148625 cites W2002633984 @default.
- W1994148625 cites W2004535570 @default.
- W1994148625 cites W2004916572 @default.
- W1994148625 cites W2005283981 @default.
- W1994148625 cites W2007052425 @default.
- W1994148625 cites W2008952536 @default.
- W1994148625 cites W2009678596 @default.
- W1994148625 cites W2010130488 @default.
- W1994148625 cites W2010820226 @default.
- W1994148625 cites W2010906660 @default.
- W1994148625 cites W2011733315 @default.
- W1994148625 cites W2013005050 @default.
- W1994148625 cites W2013766290 @default.
- W1994148625 cites W2014260144 @default.
- W1994148625 cites W2014533682 @default.
- W1994148625 cites W2014552677 @default.